A Cell is the basic unit of living organisms on Earth and has a complex organization of chemical structures called organelles. These include the nucleolus, the structure and functions of which we will examine in this article.
The Nucleated cells in its composition contain remembrance organelles rounded, more dense than karyoplasm, called nucleoli or nucleoli. They were discovered in the 19th century. Now nucleoli adequately studied through electron microscopy. Almost to the 50-ies of the 20th century the function of nucleoli has not been determined, and scientists have considered this organelle, rather, as a reservoir of spare substances used during mitosis.
Modern research has shown that organoid includes granules nucleoprotein nature. Moreover, biochemical experiments confirmed that the organelle contains a large number of proteins. They determine its high density. In addition proteids, in the composition of nucleoli is present in RNA and a small amount of DNA.
Interestingly, in the life of the cell, which consists of the rest period (interphase) and division (meiosis – sexual, mitosis – in somatic cells), the nucleoli remain volatile. Thus, in the interphase nucleus with a nucleolus, whose function – the preservation of the genome and the formation of belokrinitsa organelles are required. At the beginning of cell division, namely prophase, they disappear and re-formed only at the end of telophase, and remained in the cell until the next division or to apoptosis – her death.
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In the 30-ies of the last century, scientists found that the formation of nucleoli is controlled by certain areas of some chromosomes. They contain the genes that store information about what structure and what are the functions of nucleolus in the cell. There is a correlation between the number of nucleolar organizers and the organelles. For example, the African clawed frog contains in its karyotype, two chromosomes and NORS, respectively, in the nuclei of its somatic cells contain two nucleoli.
As the functions of the nucleolus, and its presence is closely associated with cell division and the formation of ribosomes, the organelles do not exist in highly specialized tissues of the brain, blood, and the blastomere partitioning of the zygote.
In the synthetic phase of interphase, along with comodoties DNA replication occurs an excess of the number of rRNA genes. Since the functions of the nucleolus-produces ribosomes, in connection with sverginata DNA loci that carry the information on RNA dramatically increases the number of these organelles. Nucleoproteins that are not associated with the chromosomes begin to function autonomously. As a result, the core formed many nucleon, which greatly differs from the NORS of chromosomes. This phenomenon is called amplification of rRNA genes. Continuing to examine the function of the nucleolus in the cell, we note that the most active their synthesis occurs in the prophase of meiotic division meiosis, resulting in the oocytes of the first order can contain several hundred nuclei.
The Biological significance of this phenomenon becomes clear if to consider that in the early stages of embryogenesis: crushing and blastulation, you need a huge number of ribosomes synthesizing the main building material-protein. Amplification-a common enough process, it happens in the ovogenesis of plants, insects, amphibians, yeast, and some protist.
We Continue our study of eukaryotic cells and their structures, and consider the nucleolus, structure and functions of which are interrelated. Determined that it contains three types of elements:
From the point of view of chemical analysis, this organoid almost entirely composed of RNA and protein, and the DNA is only on its periphery, forming annular structure – Okladnikova chromatin.
So we have established that the nucleolus is composed of five formations: the fibrillar centers and granular, chromatin, protein reticulum and dense fibrillar component.
The Biochemical structure of these organelles depends on the cell type in which they are present, as well as the peculiarities of their metabolism. Distinguish 5 main structural types nuclear. First – reticular, the most common and is characterized by abundant dense fibrillar material, clumps of nucleoprotein and nucleones. The process of rewriting the information with the nucleolar organizers is very active, so fibrillar centres are not visible in the field of view of the microscope.
As the main function of the nucleolus in the cell-synthesis of ribosomal subunits, which form beloksinteziruûŝie organelles, reticular typeorganization is inherent in both plant and animal cells. Circle the type of nucleoli found in cells of connective tissue: lymphocytes and endothelial cells, in which rRNA genes are transcribed almost not. Residual nucleoli found in cells that completely lost the capacity for transcription, for example, normoblasts and enterocytes.
Segregated view of the inherent cells that experienced the intoxication carcinogens, antibiotics. And finally, the compact type of nucleus characterized by many fibrillar centres and a small number of nucleons.
We Continue our study of the internal structure of the kernel structures and determine what are the functions of nucleolus in cell metabolism. It is known that about 60% of the dry weight of organoid accounts for the proteins included in the composition of chromatin, ribosomal particles, as well as for proper nucleolar proteins. Focus on them more. Part of proteids involved in the processing – the formation of Mature ribosomal RNA. These include RNA polymerase 1 nuclease that remove excess triplets from the ends of the rRNA molecules. Protein fibrillarin is located in the dense fibrillar component, as well as the nuclease, and performs processing. Another protein – nucleolin. Along with fibrillarin he is PFK and FC of nucleoli and nucleolar organizers of chromosomes of prophase of mitosis.
Such a polypeptide, as nucleophosmin, you'll be within the granular area and the dense fibrillar component, it is involved in the formation of ribosomes from 40 S and 60 S subunits.
The Synthesis of ribosomal RNA – a main task which needs to perform nucleoli. At this time on its surface (namely fibrillar centers) transcription occurs when the enzyme RNA polymerase. This nucleolar organizer synthesized hundreds of pre-ribosomes, called ribonucleoproteins globules. They are formed from ribosomal subunits, which through the nuclear pores leaving karyoplasm and appear in the cytoplasm of the cell. The small 40S subunit is connected with RNA and only after that it attaches large subunit 40S. Formed a Mature ribosome, is able to broadcast – the synthesis of cellular proteins.
In this article, we studied the structure and function of nucleolus in plant and animal cells.
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Alin Trodden - author of the article, editor
"Hi, I'm Alin Trodden. I write texts, read books, and look for impressions. And I'm not bad at telling you about it. I am always happy to participate in interesting projects."
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