Products of lipid peroxidation. Lipid peroxidation and coronary heart disease

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2018-03-23 20:32:13

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Lipid Peroxidation (LPO) is a vital link in the metabolic exchange. The main function of it is to update the lipids of cell membranes.

lipid peroxidationIn a healthy person the process of lipid peroxidation controlled by the antioxidant system which regulates the speed and activity of the phosphorylation by binding of trigger factors or neutralize sufficient quantities of peroxides to prevent excess end products of metabolism. Strengthen the oxidation process can be a starting point in the pathophysiological processes of a significant number of diseases. This process includes a stage of enzymatic and non-enzymatic auto-oxidation.

Types

To modify the phospholipid bilayer of cell membranes is enzymatic oxidation. In addition, he is involved in the formation of biologically active substances, detoxify the body, metabolic reactions. The non-enzymatic oxidation manifests itself as a destructive factor in the life of the cell. Due to the formation of a large number of free radicals and accumulation of peroxides activity of antioxidant system is reduced and, as a consequence, there is the death of cells in the body.

Cycle FLOOR

products of lipid peroxidationTo start lipid peroxidation requires the presence of oxygen free radicals with an extreme energy level of one unpaired electron. After recovery of the molecule is formed superoxide oxygen which reacts with the hydrogen atoms becoming hydrogen peroxide. To control the amount of superoxide inside the cell, there are superoxide dismutase forms hydrogen peroxide, and catalase, peroxidase neutralize it to water. If a living organism is exposed to ionizing radiation, the number of free hydroxyl radicals will increase dramatically. In addition to the hydroxide oxygen and other active forms can initiate the start of the process of lipid peroxidation.

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Products of lipid peroxidation or utilized by the body, or used for the synthesis of prostaglandins (substances involved in the reactions of inflammation), tromboksanov (included in cascade tromboobrazovania reactions), hormones of adrenal gland.

System monitoring

Depending on the underlying structure of the cell membrane the rate, the activity and the number of resulting oxidation products can vary. For example, the activity of lipid peroxidation is higher where the composition of the cell wall is dominated by unsaturated fatty acids, and slower if the basis of the COP is cholesterol. In addition, the factor controlling the quantity and rate of formation of free oxygen radicals, as well as the disposal of peroxides, are metabolic enzymes. In reaction of peroxidation of lipids involves substances that affect the lipid composition of the cell membrane and its arbitrary change in accordance with the needs of the body. These include vitamin E and K, thyroxine (thyroid hormone), hydrocortisone, cortisone and aldosterone (feedback principle). Destabilisateur the cell wall and metal ions, vitamins C and D.

Violation of the process

The Metabolic products of lipid peroxidation can accumulate in the tissues and fluids of the body, if the antioxidant system fails to recycle them with the necessary speed. Consequently, disrupted transport of ions across the cell membrane, which indirectly can affect the ionic composition of the liquid portion of blood, the speed of polarization and depolarization of the membranes of the muscle cells (to break the conduction of nerve impulses, their contractility increase refractory period), to promote the entry of fluid into the extracellular space (edema, blood clots, electrolyte imbalance). In addition, key products of lipid peroxidation, after a series of biochemical reactions, transformed into aldehydes, ketone bodies, acids, etc. These substances have a toxic effect on the organism, manifested in the decrease in the rate of DNA synthesis, increase of permeability of capillaries, increasing the oncotic pressure and, as a consequence, sludge-syndrome.

Manifestations in clinic

reaction of lipid peroxidationSince the increase in the number of free radicals of oxygen has a damaging effect on the cell wall, and metabolic products interfere with the metabolism and synthesis of nucleic acids, as well as poison the body, they are a pathophysiological factor in the development of a number of clinical conditions. The role of lipid peroxidation is important in liver diseases, joints, parasitic infectious diseases, hemodynamic disorders, cancer, trauma and burns. GENDER is one of the factors in the development of atherosclerosis. Free radicals, oxidizing cholesterol and low molecular weight fractions, forming products that damage the vascular wall. This starts a typical cascade of pathological reactions, to repair the damage. It triggers the thrombus formation, accumulation of blood clots in the lumen of small blood vessels or attaching to their walls. As a result, the movement of blood on thethe plot slows down as the vessel lumen has already become. This contributes to the further accumulation of blood clots. The most prone to such changes in the coronary arteries, aorta, manifested in the clinic as a symptoms of ischemic heart disease.

Preventive measures

the mechanism of lipid peroxidationPractitioners have to remember that carrying out diagnostic and therapeutic procedures may activate the mechanism of lipid peroxidation. This should be mentioned to the patient. By precipitating factors include radiation therapy (in Oncology), ultraviolet irradiation (with rickets, inflammatory diseases of the sinuses, antibacterial treatment rooms), magnetic fields (MRI, CT, physical therapy), sessions in the chamber (when polio altitude sickness).

Prevention and treatment

the processes of lipid peroxidationStaff working in x-ray rooms, aides and nurses, specialists in physiotherapy, climbers, people who are overweight need to eat foods containing natural antioxidants: fish, sunflower or olive oil, greens, eggs, green tea.lipid peroxidation value in Addition to diet changes, it is possible to use drugs that bind some groups of free radicals or combine with metals of variable valency. Thus they represent free molecules of active oxygen, not allowing them to contact amps the FLOOR.

Diagnostics

the role of lipid peroxidationAt the current stage of development laboratory research we are able to detect peroxide in the composition of biological fluids of the human body. You need to do fluorescent microscopy. In other words, to identify lipid peroxidation. The value of this diagnostic test needs no explanation. Because the basis of a significant number of disease is the excessive activity of lipid peroxidation. Identifying this condition determines the tactics of treatment.

From the point of view of physiology of lipid peroxidation is essential for the formation of steroid hormones, inflammatory mediators, cytokines, and tromboksanov. But when the number of metabolic products of these chemical reactions exceeds the allowable value and peroxide damage cell organelles, disrupt the synthesis of DNA and proteins, comes into action the antioxidant system that reduces the number of free radicals of oxygen, ions of metals with variable valence. In addition, it increases the synthesis of catalase and peroxidase with the aim of disposing of excess peroxides and products of their further metabolism.


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AR: https://tostpost.com/ar/health/13820-products-of-lipid-peroxidation-lipid-peroxidation-and-coronary-heart-d.html

BE: https://tostpost.com/be/zdaro-e/24696-pradukty-perak-snaga-ak-slennya-l-p-da-perak-snaga-ak-slennya-l-p-da-s.html

DE: https://tostpost.com/de/gesundheit/24719-produkte-der-lipidperoxidation-lipidperoxidation-und-koronare-herzkran.html

ES: https://tostpost.com/es/la-salud/24740-productos-perekisnogo-de-la-oxidaci-n-de-los-l-pidos-la-peroxidaci-n-d.html

HI: https://tostpost.com/hi/health/13841-peroxidation-peroxidation.html

JA: https://tostpost.com/ja/health/13843-products-of-lipid-peroxidation-lipid-peroxidation-and-coronary-heart-d.html

KK: https://tostpost.com/kk/densauly/24686-n-mder-lipidterd-as-yn-toty-uyny-as-yn-toty-u-toty-u-lipidterd-zh-ne-z.html

PL: https://tostpost.com/pl/zdrowie/24613-produkty-peroksydacji-lipid-w-peroksydacji-lipid-w-i-choroba-niedokrwi.html

PT: https://tostpost.com/pt/sa-de/24625-os-produtos-da-peroxida-o-lip-dica-a-peroxida-o-lip-dica-e-a-doen-a-ar.html

TR: https://tostpost.com/tr/sa-l-k/24691-r-nleri-lipid-peroksidasyon-peroksit-oksidasyonu-lipit-ve-koroner-kalp.html

UK: https://tostpost.com/uk/zdorov-ya/24664-produkti-perekisnogo-okislennya-l-p-d-v-perekisne-okislennya-l-p-d-v-t.html

ZH: https://tostpost.com/zh/health/14518-products-of-lipid-peroxidation-lipid-peroxidation-and-coronary-heart-d.html






Alin Trodden - author of the article, editor
"Hi, I'm Alin Trodden. I write texts, read books, and look for impressions. And I'm not bad at telling you about it. I am always happy to participate in interesting projects."

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