The Drug "Papaverine". The manual will help in the application

Among the many drugs for many years enjoys the confidence of patients, is there something like “Papaverine”. Manual describes in detail all the indications and dose of application of this alkaloid. In nature, this substance found in opium. Lately it most often produced synthetically. This substance is crystalline powder, slightly soluble in alcohol, slowly soluble in water. The powder has a slightly bitter taste. An aqueous solution of a substance subjected to sterilization 0.5 hours at a temperature of 100 °C.

The Drug “Papaverine” refers to the myotropic antispasmodic drugs. It reduces Oxytocics activity and reduces tone smooth muscles, has antispasmodic and vasodilatory effect. This drug is used as an antispasmodic in the event of spasms of smooth muscles (for cholecystitis, pilorospazme, spastic colitis, spasms of the urinary tract), peripheral blood vessels, bronchi, blood vessels of the brain. Until recently, the tool is quite often used to prevent attacks of angina. Taking medication “Papaverine" of the manual which provides information about its positive properties, it should be remembered that at higher doses it slows intracardiac conduction, reduces the excitability of the heart muscle. The drug lowers blood pressure.

Although doctors often prescribe the drug to patients “Papaverine”, the statement fails to mention that the mechanism of its action on the human body are still nesochen. That substance is an inhibitor of phosphodiesterase enzyme, causing intracellular accumulation of cyclic adenosine monophosphate. Its accumulation leads to a decrease in contractility of the muscles and relax her spastic conditions.

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Often in combination with promedolum assign means “Papaverine" manual which allows to use it in combination with other spasmolytic and analgesic drugs. Such therapy is performed to eliminate strokes. Also often prescribe it in combination with platifillina, phenobarbital and other substances.

The Drug “Papaverine” release tablets (0.04 g) in packs of 10 PCs., in ampoules of 1 and 2% solution 2 ml, rectal suppositories, 0.2 g Active substance in tablets, easily penetrates through gistogematicalkie barriers, is rapidly absorbed in the digestive tract. The drug is excreted by the kidneys. The half-life – from an hour to 2 hours. To 60% solution of the substance is excreted in the form of different compounds (glucuronic acid, phenolic).

Means “Papaverine" manual which clearly paints, in what doses to take drug to patients of all ages, require strict compliance with these regulations. Excess dosage often leads to serious consequences. Adults a day, usually require 3-4 meals a day taking the medication 1 tablet (0.04 g). Prescribe pills to children, depending on the number of years for 3-4 times a day ingestion in such dosages:

- 0.5-2 years: 0,25-0,5 tab.;

- 3-4: 0,5-1 tab.;

- 5-6: 1 tab.;

- 7-9: 1,5 tab.;

- 10-14: 1,5-2 tab.

Intramuscularly and the solution into the skin injected with 1-2 ml (1; 2%). Carefully and very slowly administered 2% solution inside the vein (1-2 ml) as the drug can cause the appearance of atrioventricular block, ventricular fibrillation and ventricular extrasystoles. In the form of suppositories means of use of 0.003-0.03 g per single dose (dosage depends on age). Candles used after the enema or bowel movement.

Contraindicated to take the drug with hypersensitivity to it, arterial hypotension, violations of atrioventricular conduction. Do not take the drug without consulting a doctor. Effectiveness or safety in lactation and pregnancy is not established. Therefore, the drug “Papaverine" of the indications of which in this period are vital, it is better not to use. During treatment it is forbidden to drink alcohol.