Pain – it's kind of the body's attempt to attract the attention of the person, call for help. It means that something is “in the state of Denmark", and the resources of the organism are not enough to resolve the problem, we need support from the outside.
In the consumer pharmaceutical market of the Russian Federation represented hundreds of drugs designed to help people cope with pain. All medications different composition, scope and mechanism of the effect. Some are the most effective drugs from the group of non-steroidal anti-inflammatory drugs. Among them are suspension and tablets “Nimesulide".
Round tablets are biconvex in shape. Color can be light yellow or just yellow. The main operating component - the substance nimesulide in each tablet-100 mg. From a number of additional can be called microcrystalline cellulose, starch (corn), chromalveolata sodium, colloidal silicon dioxide.
In addition, the drug is available to consumers in the form of powder for preparation of oral suspension “Nimesulide". The composition is the same as the pill, each sachet of 100 mg the main active ingredient.
Nimesulide selectively inhibits the cyclooxygenase-2 for cyclooxygenase-1 its effect is manifested to a much lesser extent. In this regard, there is inhibition of the synthesis of prostaglandins, triggered by the reaction of an inflammatory nature. However, the process of formation of prostaglandins regulatory type nimesulide has a barely perceptible influence that causes minimal adverse events on the part of the digestive system.
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In Addition, the effective action of nimesulide is manifested in the inhibition of free radicals. However, the processes of hemostasis and phagocytosis did not suffer the effects of this substance. In the mechanism exerted anti-inflammatory effects of the drug are of great importance and its ability to inhibit the release of myeloperoxidase (in many inflammatory diseases can provoke tissue damage, is one of the accurate diagnostic characteristics indicating the possible risk of heart attack or stroke).
Wide Enough scope medicine "Nimesulide". What helps this drug? Since the drug has on the human body is a complex effect-antioxidant, analgesic, antipyretic and anti-inflammatory, – then assign it with a number of inflammatory diseases. Effective drug and in the presence of osteoarthritis (chronic joint damage in the first place destroyed articular cartilage) tendonitis (inflammation and degeneration of the tissues of the tendons), bursitis (inflammation of the mucous bags, prevalent in the joints).
Shows Good results "Nimesulide" in the treatment of rheumatoid arthritis, extra-articular rheumatic diseases. Successfully fighting infectious diseases involving inflammatory processes. Quite often, pills "Nimesulide" used in gynecology, in the treatment of injuries of different origin. Patients say the effective elimination of the pain syndrome in the postoperative period.
Since the medication belongs to the group of modern PSPA, it has a fairly extensive list of contraindications. "Nimesulide" (from what helps the medicine – have been considered previously) should not be taken by people with hypersensitivity to any ingredient in its composition. Not prescribe the drug to those patients whose anamnesis includes hepatotoxicity and hypersensitivity reactions in the form of rhinitis, bronchospasm, urticaria (while taking aspirin or other representatives of the group of NSAIDs).
Contraindications of the medication is the presence of any erosive-ulcerative lesions of the digestive system, the tendency to develop bleeding of any origin (i.e., deviations in the functioning of the blood coagulation system).
The Cure "Nimesulide" the instruction prohibits the patients suffering from kidney, liver, heart failure. Patients with “aspirinova” asthma, alcohol and drug dependency should also not take the drug.
Do Not prescribe medication in cases if the patient has fever or have other flu-like symptoms. In addition, you should not take "Nimesulide" children, pregnant and lactating women.
The Use of medication can trigger a number of side effects from various organs and systems of the human body.
The Most frequent responses are recorded from the digestive system, and they manifest themselves by nausea, vomiting, diarrhea, development of flatulence and gastritis. Less likely to have a digestive tract bleeding site, ulcer until perforation. Occasionally you may hear about dyspepsia, stomatitis, abdominal pain.
Can cause "Nimesulide" adverse actions on the part of the hepatobiliary system, most often manifested in increased levels of liver enzymes, rarely-the development of hepatitis (including fulminant), jaundice cholestatic.
About the reaction of the cardiovascular system can tell if there has been a steady increase in blood pressure, rarely patients suffer from palpitations, hemorrhage, hot flashes, racing HELL.
The Urinary system can respond to edema (not often), at least – a delay of urine, hematuria, dysuria. Very rarely may develop renal failure, interstitial nephritis, oliguria.
Possible reactions of the Central nervous system is often manifested by dizziness, General malaise, asthenia. Rarely you can hear about the headaches, the development of somnolencia (like hypnotic sleep), Reye's syndrome (encephalopathy), hypothermia (decrease body temperature below the level required to maintain normal metabolism). Occasionally you may hear about such reactions to “Nimesulide" as nervousness, anxiety, nightmares.
With regard to the lymphatic system and hematopoietic system, "Nimesulide" (manual, reviews of health workers confirm this information) occasionally it can provoke anemia, eosinophilia, and rarely develops thrombocytopenia, purpura pancytopenia.
Rare, but can be heard on metabolic disorders (hyperkalemia), immune system (hypersensitivity, anaphylaxis), eyes (blurred vision, blurred fields), respiratory, mediastinal (dyspnea, bronchospasm, asthmatic attacks). Was the reaction of the skin and subcutaneous tissue (sweating, itching, dermatitis, urticaria, erythema, rarely-toxic epidermal necrolysis, Stevens-Johnson syndrome).
Adult patients tablets “Nimesulide" is recommended to take one (100 mg) twice a day. It is preferable to do this after a meal and to wash down the drug with plenty of water. If we are talking about powders for suspension, then the contents of one sachet diluted in 100 ml of water. Adolescents over 12 years no need to change the dose, but babies this medication to receive prohibited. In the case of the treatment of elderly patients dose adjustment is not performed.
For people suffering from hepatic insufficiency, the clearance of creatine in the range of 30-80 ml/min, the dosage is not correct. If the indicator is lowered (30 ml/min or less) – the drug is prohibited to receive.
These are the basic recommendations on taking the drug "Nimesulide". The minimum effective dose is prescribed and for the shortest period that will minimize the risk of negative effects. Maximum course of therapy with the use of "Nimesulide" should not exceed 15 days.
Taking the pill "Nimesulide" stick to the dosage recommended in the instructions or selected by the attending physician. Self-administration of medication and (or) its uncontrolled use can lead to overdose. The most frequently observed the following symptoms: nausea, vomiting, bleeding of the gastrointestinal tract, drowsiness, lethargy, hypertension (high blood pressure), depression of respiratory function, acute renal failure.
Treatment in case of overdose, symptomatic, is of a supporting character. The antidote nimesulide is currently lacking. If overdose or taking high doses of medication not passed for more than 4 hours in the hospital, the patient is lavage of the stomach, we recommend taking an absorbent (e.g., activated carbon in the amount of 60-100 mg for adults), and some laxative drug osmotic type.
Alin Trodden - author of the article, editor
"Hi, I'm Alin Trodden. I write texts, read books, and look for impressions. And I'm not bad at telling you about it. I am always happy to participate in interesting projects."
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