Diseases of the heart and blood vessels to bother a lot of people. To resolve these ailments, prescribe “Metsoc”. Instruction manual strongly recommends that before using these pills consult with the doctor and not to take the drug as it has serious contraindications. The cure assists in diseases angina, severe heart failure, tachycardia, migraines, and similar ailments.
Sold by prescription only means “Metsoc”. Instruction manual describes in detail the composition of the tablets.
For the Drug at a dosage of 25 mg contains 23,83 mg of active ingredient metoprolol tartrate, 50 mg is about 47,66 mg active ingredient and 100 mg mg. 95,32
Auxiliary substances in medicine are: hypromellose, ludipress, LA, povidone, silica colloidal anhydrous, magnesium stearate.
Bean Shell consists of a pre substance “Opadry II”, which is painted in orange color. It includes components such as polyvinyl alcohol, talc, macrogol, titanium dioxide, dye iron oxide yellow, black and red, and Indigo.
Tablets are a medication of prolonged action, they are covered in light green shell. Are round, convex on both sides.
Bean in the amount of 30 pieces Packed in plastic bottles and 10 pieces in an aluminium blister. In a cardboard box three blisters.
Producer "of Matotoka” is the Russian company JSC "Akrikhin".
Refer to cardioselective beta1-blockers tablets “Metsoc”. Instruction manual fully describes the pharmacological effect of the drug. The drug has membrane-stabilizing properties and sympathomimetic activity. Characterized by protivovospalitelnym, antianginal and antiarrhythmic action.
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In small quantities hampers β1-adrenergic receptors of the heart, reduces catecholamines activate the connection of camp from ATP, minimizes the current in the ions of calcium, forms a negative Chrono-, batmo-, dromo - and inotropic effect. At the beginning of the use of medicines increased total vascular resistance. This is due to stimulation of work of α-adrenergic blocking β2-adrenergic. After a few days (1-3) the patient's condition returns to its original state and with continued therapy, systemic vascular resistance decreases.
Protivogistaminnoe effect occurs by reducing the minute amount of blood flow and connections through the renin inhibition activity of the renin-angiotensin-aldosterone function and the Central nervous system, as well as the revival of the sensitivity of baroreceptors of the aortic arch, and in the end reduced peripheral sympathetic performance. Falling high blood pressure at rest. Decompression occurs when physical activity and psychological stress. The antihypertensive effect lasts more than a day.
Anti-anginal property arises from a decrease in the need for myocardial oxygen, which ultimately reduces the heart rate and the susceptibility of the muscle to the influence of the sympathetic innervation. Reduces the number of angina attacks and reduces their duration. Increases the physiological activity of the person. Due to the increase in the finish diastolic pressure in the left ventricle and elasticity of muscles of both ventricles increases the oxygen requirement in people with heart failure.
The Antiarrhythmic result is achieved by the suppression of the arrhythmogenic manifestations, which are expressed in the form of tachycardia, hypertension, etc. there is a reduction of unintended excitation of the sinus and ectopic rate and inhibition of AV conduction.
The presence of supraventricular tachycardia and sinus forms, detection of atrial fibrillation, hyperthyroidism and other functional diseases of heart device reduced heart rate, which in some cases leads to the restoration of sinus rhythm.
The Drug is an excellent prophylactic against migraines.
Used in the medium therapeutic doses it has no pronounced effects on the bodies β2 - adrenergic receptors and does not affect the metabolism of carbon in the body. Its effect is similar to the effect of “Propranolol”.
When taking the drug for several years can significantly decrease the amount of cholesterol in the blood. When taken daily doses from 100 mg medication affects simultaneously on all subtypes of β-adrenoceptor.
“Metsoc" (instruction manual comes with the pills) digested by 95 %. Moderately soluble in fats. Involved in first-pass metabolism and its bioavailability is 50% in the initial use of drugs and 70% the next. The maximum concentration of a substance in the blood observed after 6-12 hours after consuming the pills. In the process of continuous therapy, the bioavailability increases gradually. Food increases the bioavailability by 40 %.
Active substance 10 % connected with protein in the blood. Rather quickly absorbed by the tissues andpenetrates the blood-brain barrier, placenta. Some of it passes into breast milk.
Metabolized in the liver, two main metabolite are characterized by beta-adrenoblokiruta activities. In the metabolism of the drug is involved isozyme CYP2D6.
The half-life averages 3.5 to 7 hours. The drug is not excreted by the body by hemodialysis.
In the plural the metabolites are present in patients with CC 5 ml/min, and in this case its beta adrenoblokiruyuschee activity is not increasing.
Bioavailability is increased when the disease cirrhosis of the liver. Here, reduced the total clearance.
Responses of patients say that the drug relieves tachycardia, decreases heart pain and stabilizes mood. Indication for pill is arterial hypertension and heart failure in the chronic form, which is in the stage of compensation. In the latter case, the drug is recommended to use along with other drugs for multiple uses.
Prescribed for cardiac ischemia, the drug “Metsoc”. Indications for use in angina (stable form), reducing mortality and reducing the likelihood of reinfarction after the acute phase of the disease.
The Drug is recommended for the failures of the rhythm of the heart when a supraventricular tachycardia is present, to reduce the frequency of contraction of both ventricles during atrial fibrillation and ventricular extrasystoles.
The Drug is effective in functional disorders of the heart, accompanied by severe tachycardia. It is often used to prevent migraine headaches. It was recommended to accept the drug “Mattock" indications. Now, let's talk about contraindications.
In all cases it is forbidden to take the medicine yourself, without a doctor's prescription. Pills are not prescribed for cardiogenic shock, AV blockade II-III degree of severity. Do not use tool if sinoatrialnaya blockade syndrome weakness of the sinus node. The prohibition to eat is bradycardia (50 beats/min), heart failure in the acute, the chronic form and the stage of decompensation. Contraindicated “Metsoc" (the manual describes all the details of drug administration) hypotension, myocardial infarction, in the acute stage, severe bronchial asthma, of pheochromocytomas, violations of peripheral blood circulation. Strongly advise you to combine the medication with MAO inhibitors and intravenous injections “Verapamil”.
You should Not use the medicine to children, whose age has not reached eighteen years of age, during the period of breastfeeding, people with insufficiency and lactose intolerance, as well as the syndrome of malabsorption, hypersensitivity to beta-blockers, such as metoprolol.
With care prescribe a drug for diabetes, I degree AV blockade and angina prinzmetals. Caution should cause metabolic acidosis, a disease of the bronchial asthma and diseases of the pulmonary, hepatic and renal systems. Virtually no prescribed medication in infants, of pheochromocytomas, hyperthyroidism, depression, psoriasis, failure in peripheral blood circulation, pregnancy and the elderly.
Clinical studies on the influence of the drug on pregnant women have not been conducted. There is also no data on the degree of penetration of the drug into breast milk. Therefore, in the period of carrying a child and lactation before the use of pills need to consult a doctor.
Some patients report that the drug can cause side effect fatigue. It is therefore important to follow the rules of admission and the recommended dose. If the doctor is not picked up treatment individually, it is necessary to drink according to the classical scheme tablets “Metsoc”. Instruction manual recommends to use the drug once daily in the morning regardless of food intake. Dragees not chewed and washed down with a small amount of water. To avoid bradycardia, the dose of medicine gradually increase.
The presence of angina and hypertension treatment starts with 50 mg per day. If the effect was not achieved, the daily dose may be increased to 100-200 mg/day, and hypertension - in some cases - therapy complement another antihypertensive drug.
For people with chronic heart failure class II according to NYHA classification, without the aggravation of stages for six months without significant changes in treatment over the past fourteen days, provided the initial dose is 25 mg once a day. After two weeks, if necessary daily dose increased to 50 mg and then after another two weeks, up to 100 mg and the same period (14 days) increase to 200 mg.
At the III-IV class chronic heart failure treatment starts with 12.5 mg once a day and only two weeks from this numberincrease to 25 mg and so on until reaching the maximum daily dose of 200 mg. for this diagnosis the patient at higher therapeutic doses should be under the close supervision of a doctor, as some patients the condition may be exacerbated.
Apply the medication in secondary prevention of myocardial infarction and failure of the heart rate in therapeutic daily dose of 100 mg.
Patients with functional disorders of the heart, in which there is a tachycardia, drug prescribed 50 mg per day. If necessary daily dose increased to 200 mg.
To prevent migraines the drug is recommended to drink 100-200 mg per day.
Do Not adjust the therapeutic dose for the elderly and patients with renal failure on hemodialysis.
Liver Disease affect the removal of metoprolol from the body, so in this case, during treatment, adjust treatment dose regardless of the patient's condition.
The Need with caution and only on doctor's orders to take the pill “Metsoc”. The manual describes contraindications, under which this medication is not possible. Experts emphasize that failing to follow the dosage and admission rules can occur to overdose, which is accompanied by ventricular premature beats and tachycardia, feeling of heaviness in the head, hands and feet, as well as a significant increase in blood pressure.
The Treatment is carried out by intravenous injection of alpha-blockers and beta-blockers.
As already mentioned, in some cases, the drug “Mattock” can experience side effects. According to patients, it can be an increase in blood pressure, acceleration of the cardiac rhythm, fibrillation of heart ventricles, arrhythmia, cardialgia and bradycardia.
From the Central nervous system, you may experience dizziness, unconscious sense of fear, anxiety, sleep disturbance, headache, muscle cramps, tremor, cerebral hemorrhage, paresthesia.
Other side illnesses, according to the doctors and their patients are symptoms such as pale skin, ischemia of the skin in the area of injection, allergies, necrosis, eschar on the surface of fabric after the introduction of subcutaneous injections.
In case of occurrence of side effects advised to stop the drug “Metsoc" instructions for use. Analogues of this medicine will help you to choose the doctor.
Are of great importance when prescribing medication, “Metsoc" indications. Analogues are used to treat such diseases are not so rare. Their picks expert, carefully evaluating the patient's condition, in that case, if the “Mattock” for certain reasons did not come.
Throughout the treatment, it is necessary to closely monitor performance of ECG, blood pressure, blood circulation in hands and feet, and also for the minute volume of blood.
Patients suffering From arterial hypertension with acute heart failure, you need to maintain systolic blood pressure at the level of 30-40 mm Hg. article.
With an increase in blood pressure, accompanied by symptoms of tachycardia or bradycardia-sometimes there are failures of the heart rhythm. In this situation, treatment with “Metsoc" (the user manual warns of possible side effects) you need to stop. To prevent secondary decrease in blood pressure after the abolition of drugs, reduce the dose gradually, especially if you've had a long infusion, and droppers continue to put the patient, if the pressure is reduced to 70-80 mm Hg. article.
In the elderly the number of adrenergic receptors, are particularly susceptible to fenilefrina, is reduced. In turn, monoamine oxidase inhibitors, increasing the compressing effect of the sympathomimetics, provoke pain in the head, arrhythmia, gag reflex, hypertensive crisis. As a result, patients who use monoamine oxidase inhibitors in 2-3 days the number of sympathomimetics decrease.
During the course of treatment the doctors are recommending to carry out a hazardous activity, which is based on quick reflexes - both mental and physiological.
With extreme caution needs to take pills persons suffering from kidney disease, and the elderly. The drug should not be taken by children under eighteen years of age due to insufficient study of its impact.
The Drug is released from pharmacies strictly by prescription.
What if, for whatever reason, did not fit the ‘Metsoc”? Counterparts always can be found in the pharmacy. They have the same active substance and in this way affect the body. Such drugs include:
These and other substitute “Metsoc” analogues have been successfully used in the treatment of cardiovascular diseases. All funds require a serious approach and is nottake yourself without prescription.
The Drug “Metsoc” feedback is mostly positive. People have commented that it is comfortable to drink (the recommended dose is one tablet a day). Talking about his productive action. Many patients say that after eating means forgot about the pain in the heart.
Experts in the field of medicine, is also strongly praised tablets “Metsoc”. The doctors indicate that this medicine effectively and safely, so it is often prescribed by cardiologists for their patients. Experts say that during treatment the main thing - to choose the right dose, otherwise you may have side effects such as fatigue, nausea, vomiting and diarrhea.
Article in other languages:
AR: https://tostpost.com/ar/health/4927-metsoc.html
BE: https://tostpost.com/be/zdaro-e/8768-preparat-metozok-nstrukcyya-pa-zhyvann-analag-vodguk.html
HI: https://tostpost.com/hi/health/4930-metsoc-analogs.html
JA: https://tostpost.com/ja/health/4927-metsoc.html
PL: https://tostpost.com/pl/zdrowie/8770-lek-metozok-instrukcja-obs-ugi-analogi-i-opinie.html
TR: https://tostpost.com/tr/sa-l-k/8776-la-metozok-kullan-m-talimat-e-de-er-ve-yorumlar.html
Alin Trodden - author of the article, editor
"Hi, I'm Alin Trodden. I write texts, read books, and look for impressions. And I'm not bad at telling you about it. I am always happy to participate in interesting projects."
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