Biochemical analysis of blood. ALT and AST: explanation indicators

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2018-11-26 20:00:45

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Alanine aminotransferase, or ALT, and aspartate transaminase, or AST, are enzymes contained in the cells of the body, and are involved in amino acid metabolism. They are located only in the cells of the organ tissues and in the blood fall exclusively when there is a disintegration of the cells in traumatic injuries or pathologies.

Diseases

Excessive content of ALT indicates the development of pathology in the cells of which it is the highest number. The increase in alanine aminotransferase are liver pathology. Discomfort and pain in the right hypochondrium, diarrhea, icteric staining of the skin and mucous membranes, flatulence, belching, bitter – signs of an increase in ALT. The study of blood to increased ALT and AST with increased levels of bilirubin, when the development of hepatitis. Most of the increase in the content of ALT indicates the occurrence of other diseases. The concentration of ALT has a direct relationship to the degree of gravity of pathology.blood test Alt and AST transcript

Necrotic process in cardiac muscle causes the release into the blood of these enzymes. Increased their content in the serum also speaks to the development of other cardiopathology: failure, inflammation of the heart muscle. Additionally, the increase in concentration of ALT in the serum may be available in the body trauma associated with muscle tissue damage, and pancreatitis.

Biochemical analysis of blood for ALT and AST may indicate liver disease, pancreas, heart. When cardiosphere concentration of AST increases several times, and ALT — a little.

Indications for

Organs of the human body contain different amounts of enzymes ALT and AST, therefore, the increase in the concentration of a specific enzyme indicates the defeat of the body: Alt and AST blood test transcript

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• ALT found primarily in liver, heart, kidney and pancreatic cells. In the case of destruction of these organs in the blood released many ALT. Then for confirmation of the diagnosis is necessary to study precisely an alanine aminotransferase.

• AST is mainly found in the nervous, muscular, hepatic and cardiac cells, and in small quantities in the cells of the pancreas, lung and kidney tissues. Therefore, in this case, it is necessary to study on aspartataminotransferaza.

Blood test ALT and AST (transcript) indicates the condition of the organs. The increase indicates the damage of tissues, where these enzymes. And, accordingly, decrease indicates recovery. A small increase in ALT in the first trimester of pregnancy is allowable, however, you need to re-examine the blood on aminotransferases to exclude liver damage.

Biochemical analysis of blood (indicators of ALT, AST) is prescribed when the suspect cardioport, they serve as an early symptom of this acute pathology. Transcript of AST in the biochemical analysis makes it possible to diagnose and to monitor the dynamics of other modifications of the cardiac muscle, hepatic diseases and diseases of the striated muscles.

Preparation for blood sampling to conduct the study

Blood for biochemical analysis taken in the morning on an empty stomach from Vienna. At the time of the analysis must pass 8 hours. from the last consumption of food. In 24 hours. before blood sampling prohibited the use of alcohol and fried and fatty foods. It is recommended to reduce fiznagruzki. deciphering blood test Alt AST normalAfter the ultrasound, radiographic, fluorographic studies, colonoscopy or physiotherapy the blood is also not recommended to select for analysis, otherwise it will be distorted decoding of biochemistry. Over 1-2 weeks. before biochemical study need to stop taking drugs. When to comply with this condition impossible in the direction of analysis a doctor makes a remark about taking medications and their dose. Biochemical blood test (ALT, AST) may influence heavy fiznagruzki, as well as the use of alcohol and conduct of hemolysis.

Transcript analysis of the blood – ALT, AST: normal

What is the number of these enzymes should be present in healthy human blood? Conducting biochemical blood test (ALT, AST), the rate for women varied from 31 to 35 units per liter of blood. For men the figure is slightly different. The norm of ALT in the blood of men (biochemistry) - 41 to 50 u/l in newborns (up to 1 month.) normal indication corresponds to 75 units, from 2 to 12 months. – no more than 60 units, and from one year to 14 years-less than 45 units. A blood test (ALT, AST) with a high reading can indicate cirrhotic damage or acute inflammation of the liver, is stagnant or hemolytic jaundice, other liver pathology (tumors in.), angina under attack, acute rheumatic heart disease, cardiomyopathy, bile stasis, thromboembolic disease pulmonary embolism and acute pancreatitis. biochemical analysis of blood transcript of Alt AST normalThe ALT and AST blood test (transcript) with the increase of indications observedin traumatic injuries, cardiac intervention or at angiocardiography. Increased rate of AST in 20–50 times in some cases, evidence of hepatic pathology accompanied by necrosis and hepatitis of viral etiology. The elevated levels of AST 2-5 times maybe to talk about the disease with hemolysis, muscle injury, acute pancreatitis and gangrene. When degenerative phenomena in muscles and dermatomyositis observed 8-fold increase in AST.

Coefficient Ritis

With the aim of obtaining accurate answers blood ALT and AST (transcript) shows the indicators transferases. This ratio shows the de Ritis coefficient, carried out in one study serum. In the case when the number exceeds the norm (N = 1,3), this indicates the presence of cardiospectra, and when it is below the normative figures – about viral hepatitis.

Since aminotransferases are tissue localization, deciphering blood test AST shows the pathology of the myocardium, and ALT-liver, that is, the presence of cell decay:biochemical analysis of blood for Alt and AST

• When is exceeded 2 or more times, in the heart determine the heart attack.

• blood ALT and AST (transcript) demonstrates a significant excess – is evidence of infectious hepatitis in the incubation period.

• the decline of aminotransferases – the body of pyridoxine. Here is necessary differential diagnosis with pregnancy.

Tactics

In normal serum transferases exist in small volumes. All options increase the level of aminotransferases must be subjected to investigation. biochemical analysis of blood indices Alt AST

For a start needs to be repeated biochemical blood test (ALT, AST). Re-examination of some individuals (donors) in about a third of the cases shows a normal level.

Next you need to carefully collect medical history and conduct a complete examination.

The Role of history in carrying out decryption

Medical History means information about the intake of medications, blood transfusions, the presence of the syndrome of jaundice or hepatitis, family liver disease or presence of a cirrhotic process in it, abdominal pain, cancer, diabetes, obesity or, conversely, rapid weight loss.

The family of liver disease is alcohol abuse, Wilson's disease, etc.

If ALT and AST blood test (decrypt) showed above normal levels less than two times, it is necessary to organize monitoring and 2-fold tests. Such tactics are optimal for patients.

Blood test ALT and AST-decoding in some diseases

The Slight increase in transferases indicative of fatty liver damage in non-alcoholic type, including "fatty liver" of the non-alcoholic steatohepatosis, viral hepatitis, in the chronic form.

A Moderate increase in may exist in viral or alcoholic inflammation of the liver and different chronic liver disease with cirrhotic damage.

Elevated levels of typical acute hepatitis is severe, toxic or medicinal necrosis, shock, or hepatic ischemia.

Excessively high levels (over 2000-3000 U/l) exists in case of overdosing of acetaminophen and the use of funds from alkogolizatsii patients in shock and/or hepatic ischemia.biochemical analysis of blood transcript of Alt AST

It Should be noted, since ALT is in the erythrocytes, it is necessary to prevent their decomposition during the preparation of serum for analysis. ALT may decrease during storage of serum for several days.

The Role of medicines, herbs and other substances

A Thorough history and decoding of the laboratory results is essential for identifying drug-induced increases transferases. Similar liver damage detected in 1-2% of cases of inflammation of the liver in the chronic form. They are associated with antibiotics, antiepileptic drugs, inhibitors hydroxymethylglutaryl-COA reductase inhibitors, nonsteroidal anti-inflammatory drugs and medicines for the treatment of tuberculosis.

The easiest method to determine the dependence of the increase in aminotransferases with some tool – abolish it, and to observe the level of enzymes. No cancellation means that dependence is impossible to determine.


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Alin Trodden - author of the article, editor
"Hi, I'm Alin Trodden. I write texts, read books, and look for impressions. And I'm not bad at telling you about it. I am always happy to participate in interesting projects."

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