The drug "Arlet": instructions for use, contraindications, composition, and reviews

Once the development of a simple penicillin became a panacea for a range of diseases of bacterial nature from which people in most cases were killed. Since mankind stepped into another Millennium, and has developed a number of medical antibacterial drugs as broad-spectrum, and sensitive to certain strains of microorganisms. One such tool is the ‘Arlet”. Instructions for use of this medication contains complete information about all its properties.

Composition antibacterial agents

The main components are of amoxicillin trihydrate (equivalent to amoxicillin possible volumes of 250, 500, 875 mg) and clavulanate potassium (volume – 125 mg, based on klavulanova acid). The first component relates to the penicillin of a series of semisynthetic, characterized by a wide range of antibacterial activity. The second main component of drug is an irreversible inhibitor of beta-lactamase.

In addition, there are a number of auxiliary components included in the drug “Arlet”. Instructions for use, description of the drug is brought to the attention of the consumers that in the core are low-molecular povidone, pregelatinized starch, calcium stearate, microcrystalline cellulose, and talc. And that's not all.

The shell of the antibiotic form a polymer, propylenglycol and polyethylene glycol 4000 (4000 or macrogol), titanium dioxide. Weight one pill “Arlet" (instruction manual contains this information) is 600, 1100 or 1600 mg.

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Pharmacodynamics

As mentioned earlier, “Arlet” is a complex of amoxicillin and clavulanic acid. The latter forms a persistent complex is inactivated with beta-lactamases (bacterial enzymes, the main function of which consists in the response to beta-lactam antibiotics, the most widely used to carry out antimicrobial chemotherapy – cephalosporin, penicillin, etc.). Beta-lactamases responsible for creating persistent opposition to the above-mentioned medical facilities.

By Itself, the clavulanic acid, whose structure is similar to that of beta-lactam drugs, is characterized by a relatively weak antibacterial abilities of their own. Nevertheless, the presence of acid in the product is “Arlet” is opposed to the destruction of amoxicillin and increases the scope of its anti-bacterial capabilities, including bacteria and micro-organisms which under standard conditions is resistant to the effects of amoxicillin, other means of the groups of penicillins and cephalosporins.

Antibiotic “Arlet" instructions for use reglamentary as a drug with a wide scope. It exhibits activity against amoxicillin-susceptible strains (including those that synthesize beta-lactamase). These include a number of gram-positive and gram-negative aerobes and anaerobes.

Indications for use means “Arlet”

The Area influence antibacterial agents is quite extensive, it is effective in a wide range of infections of different etymology. “Arlet" instructions for use allow to eliminate problems with the upper respiratory tract and ENT-organs. In particular we are talking about acute and chronic forms of sinusitis and otitis media, tonsillitis, pharyngitis, abscesses in the retropharyngeal area. The positive impact the drug has in the treatment of diseases of the lower respiratory system, which include bronchitis (chronic and acute, accompanied by bacterial superinfection) and pneumonia.

This is the area where applied Arlet. Instructions for use, description of the medication have reported effectiveness in the treatment of diseases of the genitourinary system and the pelvic organs. Such diseases include pyelonephritis, prostatitis and urethritis, endometritis and vaginitis bacterial nature septic abortion, gonorrhea, etc.

Also positively affected by an antibiotic in the treatment of infections of skin and soft tissues of different origin (abscesses, cellulitis, erysipelas, impetigo, wound and re-infected dermatoses). “Arlet” can be used in the treatment of bone and connective tissue, while propecianeo biliary tract (cholecystitis, cholangitis), odontogenic lesions, for prevention of inflammatory processes in surgery, in the postoperative periods.

Dosage and application methods

For drugs “Arlet” method of administration and doses are determined individually and depend on the age, weight, condition of the kidneys and severity of the infection. In order to minimize the chance of developing unwanted effects from the blood, taking pills should before eating, as a whole, do not chew or take with water.

Patients older than 12 years of age or with body weight more than 40 kg in mild and moderate forms infections take one tablet (250 mg of the main component), three times a day or twice a day (500 mg amoxicillin). In severe lesions take a dose equivalent to 500 mg of amoxicillin three times a day or 875 mg – twice duringdays.

Patients aged 6 to 12 years “Arlet" instructions for use recommends the use of in recalculation on 1 kg of body weight: amoxicillin – 20-30 mg, clavulanic acid – 5-7. 5 mg. the dose for these patients is 1 tablet (250 mg) twice or thrice daily or 1 tablet (500 mg) twice a day. In severe cases dose may be doubled.

For patients with disorders in functioning of the kidneys, the dose and the reception frequency are adjusted depending on the clearance of creatine. Those who suffer from anuria, the intervals between doses is recommended to increase up to 48 hours or more. For patients on hemodialysis, the amount of the medication is chosen based on the maximum dose of amoxicillin.

People with disabilities in the functioning of the liver care during their treatment with “Arlet”. Usage instructions (summary), reviews health professionals recommend continuously monitoring this body.

For elderly patients dose adjustment is not required.

Adverse events

A list of side effects contains to antibiotic “Arlet" instructions for use. Treatment (patient testimonials confirm) this tool can cause a number of abnormalities of the gastrointestinal tract in the form of lack of appetite, nausea, vomiting, diarrhea. Occasionally you may hear about violations of the liver, more rarely – about the development of cholestatic jaundice, hepatitis, colitis pseudomembranosa.

The Reaction of the CNS to the drug “Arlet” can be headaches and dizziness, hyperactivity (reversible form) and seizure activity.

The hematopoietic System can respond to symptoms of leukopenia, hemolytic anemia, agranulocytosis. May increase prothrombin time (in this case, the process is reversible). Crystalluria and interstitial nephritis – possible implications of the drug from the urinary system.

A wide range of possible allergic reactions to antibiotic “Arlet”. Instructions description of the drug inform consumers about the possible development of pruritus, urticaria, erythematous rash. Occasionally you may hear about symptoms of erythema multiforme exudative, angioedema, anaphylactic shock. There is information about rare manifestations of side effects in the form of Stevens-Johnson syndrome and exfoliative dermatitis.

Contraindications for use “Arlet”

The List of reasons that limit the use of antibiotics contains medicine to “Arlet" instructions for use. Contraindications limit intake to those patients who suffer individual hypersensitivity to the main and auxiliary components of the drug to other beta-lactam antibacterial agents (penicillins, cephalosporins, etc.). Do not appoint “Arlet” and those who in history has record of violations of liver function during treatment with amoxicillin and clavulanic acid in the complex. The drug is contraindicated for those who suffer from mononucleosis and lymphocytic leukemia due to the increased probability of the development of exanthema.

The basis for the refusal of treatment with this antibiotic are chronic renal failure and children up to age 6 years.

With regard to pregnant women, they may take “Arlet” only when benefit to the mother is undeniable greater than the perceived risk to the fetus. During lactation the main components of the medication in small amounts enter breast milk, so you should discuss with your doctor the issue of avoidance of breastfeeding.

Excessive amounts

Disorders of the digestive tract – these are the main group of symptoms of overdose “Arlet" (tablets). Usage instructions reviews, patients have reported vomiting, diarrhoea, pain in the abdomen. Furthermore, possible conditions such as insomnia and dizziness, agitation. It is very rare to hear about the seizures.

If you have symptoms of overdose optimal solution for the patient – to be under the supervision of a specialist. Treatment in such situations, symptomatic.

If the fact of receiving an unacceptably high dose was not more than 4 hours ago, it is necessary to wash out the stomach and take drugs-absorbents (e.g., activated carbon) in order to minimize the suction. For removal from the body amoxicillin and clavulanic acid is effective hemodialysis.

Interaction with other substances and medical preparations

In a parallel admission “Arleta” and “Methotrexate" will increase the toxicity of the latter. Significantly reduced and will slow down the absorption of the treatment with antacids, glucosamine, aminoglycosides. Ascorbic acid, on the contrary, will increase absorption - this information contains about the antibiotic “Arlet" instructions for use.

The Price of medication varies depending on dosage and region, but they are available a wide range of consumers. Therefore, it is necessary to consult with your doctor and notthemselves to combine the antibiotic with other drugs.

“Arlet” magnifies the effect of indirect anticoagulants due to inhibition of intestinal microflora, reducing the production of vitamin K and reduce prothrombin index. In parallel with the reception of drugs-anticoagulants, it is important to conduct constant monitoring of indicators of blood coagulation. Decreases effectiveness of oral contraceptives.

NSAIDs, diuretics and other medications that inhibit tubular secretion, increase the concentration of amoxicillin in the blood.

Tandem “Arlet” with ‘Allopurinol” can cause the development of the exanthema. Bactericidal antibiotics lead to a synergy of action, and drugs with a bacteriostatic mechanism of the effect – antagonism.

Special instructions

For the reason that the drugs “Arlet" (instructions for use contains such information) with different dose of amoxicillin include, however, the same amount of clavulanic acid (125 mg), it should be borne in mind that two pills 250 mg of amoxicillin are not equivalent 1 tablet 500 mg of this substance.

It should Also be borne in mind that large quantities of amoxicillin can cause a false positive response when determining the level of glucose in the urine in the case if the analysis applied tools such as Benedict's reagent or a solution of Felling. Better in such cases to use enzymatic reactions with glucosidase.

The application of antibiotic courses should be a regular monitoring of the functions of the organs of hematopoiesis, liver and kidneys. “Arlet” in the recommended amounts does not affect the ability to drive vehicles and perform work requiring increased attention and speed of psychomotor reactions.

Range of prices and customer opinion about the product

For Information about the possible dosages of the basic components in the composition of the drug includes to “Arlet" (tablets) instructions for use. Price, as mentioned earlier, depends on dosage and region where you purchased the drug. For example, tablets in the shell film at a dosage of 875 mg + 125 mg in Moscow can be purchased for an amount in the range from 270 to 310 rubles (14 pieces per pack). In St. Petersburg the same package will cost 278-282 of the ruble.

As for the opinion of patients about the medicinal product, that is both positive and negative feedback about the drug. A large group of patients said about the beautiful effect in the treatment of diseases of ENT organs and respiratory tract. Medication effectively and quickly relieve sinusitis and the period of remission then long enough. Its effectiveness in the treatment of bacterial infections is also confirmed by a review patients.

The Negative reviews of the drug “Arlet” are often the result of the presence in patients of hypersensitivity to components of drug. In such cases, people often talk about deviations in the functioning of the digestive tract, such as dyspepsia, nausea and vomiting, diarrhea. Of any more severe deviations is almost no information.

However, it is worth saying that if this antibacterial agent was prescribed by the attending physician and optimal dose, all sorts of side deviations are extremely rare. If something like this happens, the doctor will select a similar effect and efficiency of analog the benefit of the pharmaceutical market in Russia is saturated by antibiotics with a broad spectrum of effects.