A large group of drugs of the tetracycline antibiotics

The tetracycline Antibiotics – this is a pretty broad group of drugs. The drugs have similar chemical structure. It should be noted that these funds are one of the leading drugs of broad spectrum of activity.

The tetracycline Antibiotics. Description

Drugs in this group have a dampening effect on the reproduction and development of gram-negative, gram-positive bacteria, sticks (acid-resistant), large viruses, and other microbes. In the category includes drugs such as “the Hydrochloride chlortetracycline”, “Oxytetracycline hydrochloride”, “Tetracycline” and other. Study medication was started in 1948 year. In connection with certain difficulties in obtaining synthetic drugs today is created with biosynthesis. All tetracycline antibiotics are different amphoteric character. Their main quality due to the dimethylamino group. Their acidic properties of the compound show due to phenolic hydroxyl in the D-ring. Being amphoteric, compounds soluble in acids and alkalis, forming a salt. They, in turn, undergo hydrolysis in aqueous solutions. High acid content prevents the process of hydrolysis and precipitation of the base.

All tetracycline compounds have spectra that are similar. In the molecules of the phenolic hydroxyl causes the change of color in the interactions with ferric chloride (3). The tetracycline antibiotics are decomposed by alkali before the formation of isometricview. In turn, this was accompanied by increased staining. The reaction of a General nature common to all tetratziklinove connections. To distinguish drugs from each other probably due to the different coloration under the influence of sulfuric acid (concentrated). Thus the formation of compounds, painted for each tetracycline in a specific color. So, for example, for one appears purplish-red hue, for the other – purple. One of the characteristic features is the ability of the drug to fluoresce under the influence of UV-light. It is often used as proof of authenticity.

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Pharmacological properties of tetracycline

This drug has a broad spectrum activity. Its bacteriostatic effects are due to inhibition of protein synthesis of the bacteria that cause. The activity of the drug is relatively gram-positive aerobic microbes, including strains, producyrute penitsillinazou. The drug also affects gram negative bacteria. Are resistant to medication small viruses, most fungi, and a number of other strains.

Some rules of antibiotics. Adverse reactions

We recommend the use of drugs in the dose of 0.3 grams in the first two days, 0.2 g five times on the following days. Gonorrhoea (uncomplicated subacute and acute) at the rate prescribed for 5 g, with other forms – 10. Recommended to take the medicine before or during a meal. Application of the probable upset stomach, vomiting, and nausea.