Neuron specific enolase: description, metrics, and decoding

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2019-08-05 21:00:28

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In medicine, there is a lot of unknown to the common man terms. One of them is neuron specific enolase (of the specific enolase). In this article we will disclose the definition of the term affected by the content of the IE in the blood, learn about the diseases that are associated with it. We will also consider the General description as the enolase enzyme.

General information

Enolase (of posterolateralis) is an enzyme involved in the final stage of glycolysis. Enolase is a biological catalyst that influence the transition 2-phospho-D-glyceric acids in the form of phosphoenolpyruvate. The acid lost in the course of cleavage of one molecule of water.

neuron specific enolase in adults

There are 3 gene responsible for encoding the isoenzyme enolase:

  1. G ENO 1. Encrypts the data about alpha enolase consisting of 2 alpha subunits. Alternative type of translation leads to the formation of the ICC-binding protein, which may reduce the efficiency of the proto-oncogene c-myc. It is found deep in the cytoplasm of many cells.
  2. G ENO 2. Encrypts data enolase 2, or gamma-enolase - the enzyme consists of 2 gamma-subunits. It is also referred to as neuron-specific enolases. Most often they are composed of neuronal cells.
  3. G ENO 3. Encrypts data enolase 3, or beta enolase the enzyme consisting of 2 subunits. Over 90% of the activity enolase type that is observed in human muscle after 23-25 years, provides this type of enzyme. Beta-enolase, respectively, located in the muscle tissue.

Enolase – superfamily, a group of enzymes that have been associated with evolution. They perform a similar range of functions in different processes biochemical nature.

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The IE in the blood

neuron specific enolase normal

The rules of neuron specific enolase can vary within a small range. However, the serum level should not exceed 13,2 ng/ml.

The IE – an enzyme of the glycolytic type. It is used as a marker of tumors of neuroendocrine nature. The IE is in the cytoplasm of cells of neuroectodermal origin in the neural cells of the brain and the PNS. The increase in the concentration of this enzyme can occur in the formation of small cell lung cancer or neuroblastoma, leukemia, after the sessions of radiation therapy and radiology after medical tests and studies. If neuron specific enolase increased to 20 ng/ml, it is possible to have benign lung disease. Because of this, the clinical diagnosis of malignant tumors registers them with the value of 25 ng/ml. due to the fact that the IE is present in the cells of erythrocytes, hemolysis increases its value and overstates the results of tests and experiments.

Diagnostics

Tests to check the level of neuron specific enolase (NSE) is prescribed for the diagnosis and monitoring the effectiveness of therapy in the treatment of small cell lung cancer. When combined use with NSE, CYFRA -21-1, it becomes possible to increase the sensitivity of diagnostic tools (in the determination of carcinoma in the lung) to 62 %. The use of the IE together with CEA allows to increase the sensitivity of tests for 57 %.

Neuron specific enolase is a valuable indicator in the diagnosis of neuroblastoma. With the point of separation 25 ng/ml the sensitivity for this marker in such tumors may reach 85 %.

Biochemistry

neuron specific enolase improves

Neurospecific enolase is a glycolytic enzyme. Its molecular weight is 80 kDa. It the above mentioned three types are also called dimers. The difference forms manifested at the level of properties, but they all have immunological beginning. It is important to know that the neurospecific enolase carry λ- λ and α- λ isoforms of gamma-enolase. It was originally discovered in the nervous and neuroendocrine cells. The IE also found in tumors.

The Concept of oncomarker

NSE – this serum is a substance that serves as anamacara for the diagnosis of tumors from cells of the APUD system, which are in various types of tissues. Also it is used when searching for neuroendocrine sources of disease. In the category of such diseases include retinoblastoma, neuroblastoma, medullary thyroid cancer, pheochromocytoma, carcinoids, and small cell lung cancer (SCLC) and cancer of the islet cells of the pancreas. An indicator of the activity of the enzyme is correlated with the clinical situation and finds application in the monitoring of pathologies, as well as forecasting. Rarely can be applied in special cases of neuroblastoma and SCLC.

The history of the discovery and study of the IE is closely linked with the study of the brain of rodents, because biochemistry, for example, white mice are very similar to ours, human.

neuron specific enolase improves the child

Concept isoforms

Neuron specific enolase (NSE, a) – an enzyme required for the stages of glycolysis. Therefore, it is present in all cells of a multicellular organism. It is important to know that the IE is tissue-specific.

Specifically, the NSE characteristicneural cells that have certain characteristics of its structure. These traits affect the normal functioning of this enzyme with increased concentration of ions Cl (chlorine). In addition to the neural cytoplasm, NSE, for example, in chromaffin cells of adrenal medulla, parafollicular cells of the type pertaining to the thyroid gland.

In a tumour cell increased synthesis of this enzyme, which allows a high speed of the process of glycolysis. Because of this, there is an active growth of the tumour, its spread in the surrounding tissues.

term neuron specific enolase

The IE and children

If neuron specific enolase is elevated in the child, this does not mean that it is necessary to sound the alarm. Often in medical practice there are cases when caring parents have resorted to surveys of the IE in the serum on its own initiative. This may be certain preconditions and causes, for example, often disease related to lungs. But research of this type is not specific that it is important to remember. The term “non-specific” implying that the measurement of the desired oncomarker can vary greatly. It depends on many conditions which are associated with the physiological characteristics of the organism and illnesses.

neuron specific enolase in children

Most importantly, this diagnostic measure will not be correct with respect to the child. This is due to the “atypical” there are many diseases that could lead to an increase in neuron specific enolase. With the exception of congenital diseases that are inherited or formed in the course of random mutation. If your child is frequently suffering from diseases affecting the lungs, we need first to produce the tank. the sowing of the oral cavity. You may need treatment with antibiotics. The use of methods with the identification of the level of NSE can be justified if they are prescribed by a qualified doctor.


Article in other languages:

AR: https://tostpost.com/ar/health/18777-enolase.html

BE: https://tostpost.com/be/zdaro-e/35863-neyronspecificheskaya-enolaza-ap-sanne-pakazchyk-rasshyfro-ka.html

DE: https://tostpost.com/de/gesundheit/35522-neyronspecificheskaya-enolaza-beschreibung-indikatoren-und-entschl-sse.html

JA: https://tostpost.com/ja/health/18458-neuron-specific-enolase-description-metrics-and-decoding.html

KK: https://tostpost.com/kk/densauly/36164-neyronspecificheskaya-enolaza-sipattamasy-k-rsetk-shter-zh-ne-ma-ynasy.html

PT: https://tostpost.com/pt/sa-de/37127-neyronspecificheskaya-enolaza-descri-o-indicadores-de-desempenho-e-de-.html

TR: https://tostpost.com/tr/sa-l-k/32613-neyronspecificheskaya-enolaza-a-klama-g-stergeler-ve-ifre-zme.html

ZH: https://tostpost.com/zh/health/6498-neuron-specific-enolase-description-metrics-and-decoding.html






Alin Trodden - author of the article, editor
"Hi, I'm Alin Trodden. I write texts, read books, and look for impressions. And I'm not bad at telling you about it. I am always happy to participate in interesting projects."

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