Drug "Divigel" for the growth of the endometrium: the reviews of doctors and of patients, dosage

The Problem of female infertility in our time is quite acute. The reasons may be different-from various inflammatory diseases of genital organs and to problems in the endocrine system. One of the common causes – this is an insufficient amount of female estrogen. Their main task-to prepare the inner layer of the uterus to accept the egg.

To eliminate this deficiency, doctors prescribe women with medicines that contain the hormone. One such remedy is the ‘Divigel” for growth of the endometrium, feedback from patients about him positive, and many women can safely get pregnant.

Drug

“Divigel” produced by the manufacturers in the form of a transdermal gel, used to eliminate signs of low estrogen. It is a uniform composition and packaged in aluminum packages.

The gel has:

• Estradiol 500 mg or 1 g.
• Carbomer 974Р.
• Triethanolamine.
• Propylene glycol.
• 96% ethyl alcohol.
• Purified water.

Pharmacological action of the drug

“Divigel” refers to a group of medicines which are used for correction of the disorders caused by menopausal period in a woman's life. It has estrogenic action.

The Therapeutic effect after the application is achieved due to the activity of estradiol. It is an estrogenic agent, which contains the ‘Divigel” for growth of the endometrium, in its biological, chemical and pharmacological properties identical to endogenous estradiol secreted by the ovaries in the female body.

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If you look at the classification of medicines, estradiol belong to several pharmacological groups:

1. Estrogens, progestins, their homologues and antagonists.
2. Anti-hormonal agents and antagonists of hormones.

Active substance of the drug compensates for a lack of female hormones and stimulates the activity of estrogen receptors located in target cells.

Pharmacokinetics

The Estradiol contained in the gel by diffusion in freely into target cells, where it is transported to the nucleus and forms a bond with estrogen receptors. Such receptors are found in different tissues. But most of them contained in the uterus, liver, ovaries, bones and Breasts.

Active component of the gel-17-beta-estradiol – has the following effects:

• Stimulates the development of female reproductive system.
• Causes pigmentation around the nipples.
• Provides rejection of the endometrium which lines the uterus.

• Provides a regular menstrual cycle.
• Stop the production of breast milk.
• Has a procoagulant effect.
• A positive Influence on the recovery of leukocyte count after radiation damage.

Estradiol is still a lot of important qualities which include:

• Prevention of atherosclerosis.
• Increase in blood levels of HDL.
• The Decline of LDL.
• Reducing the amount of cholesterol.

After the onset of menopause in a woman's body, the ovaries cease to produce estradiol, this feature remains in the liver and adipose tissue. The decline in estrogen levels leads to the fact that there is vasomotor instability, as expressed in the tides of blood to face, problems with sleep.

Another negative consequence of the lack of estrogen is osteoporosis. This metabolic disease in the first place captures the spine.

When receiving estradiol orally in the form of tablets, injections, there is a gradual accumulation in the body of this substance, which leads to a significant jump in blood pressure. “Divigel” for growth of the endometrium reviews in this respect is positive, the patient while taking no note of hypertension.

The Gel is made on the basis of alcohol, but after contact with skin, the ethanol evaporates quickly and the active ingredient penetrates through the skin and absorbed into the blood. A small amount of estradiol is delayed in the skin and then gradually released into the bloodstream.

During the course of treatment ‘Divigel” the ratio between estradiol and estrone ranges from 0.4 to 0.7. The bioavailability of the drug – 82%. The effectiveness of therapy will depend on how to apply “Divigel” for growth of the endometrium.

Readings

This gel doctors recommend to adopt as hormone replacement therapy to women who have had estrogen lack, for various reasons. The drug is often prescribed to eliminate climacteric syndrome.

The Gel has proven itself as a preventive means, prevent the development of osteoporosis. Positive feedback has the ‘Divigel” for growth of the endometrium in IVF as a product that supports a healthy pregnancy.

The Drug is administered in an individual dosage, which is chosen by the attending physician in the clinic where the procedure was carried out fertilization. To put it better a couple of weeks beforefertilization and continue after him for about a month.

After pregnancy termination application cannot be made sharply, because in this case there is a danger of miscarriage.

If there is ‘Divigel” for growth of the endometrium, the dose is prescribed in each specific case separately. During the planning of pregnancy, the doctor must verify the existence of hypoplasia of the endometrium and to stimulate ovulation it is advisable to use gel to combine with other hormonal drugs. In each of these cases, the treatment regimen will differ.

Contraindications

Before you figure out how to take the ‘Divigel” for growth of the endometrium, you must ensure that no contraindications to this, and the drug is sufficient amount. Among them often are the following:

1. Hypersensitivity to the components.
2. The Presence of breast cancer or if it has been in history.
3. Malignant tumors in the ovaries, the uterus.
4. The Presence of benign tumors in the genital organs, in the chest.
5. Predisposition to uterine bleeding.
6. Hyperplastic processes of the endometrium.
7. Pituitary tumor.
8. Inflammatory diseases of the genital organs.
9. Elevated levels of estrogen.
10. Venous Thrombosis.
11. The Presence of tumors in the liver.
12. Signs of cerebrovascular disease.
13. Sickle cell anemia.
14. Impaired fat metabolism.
15. Diabetes.
16. Middle ear Disease.

Special care while using the gel it is necessary to observe women who have:

• Asthma.
• The migraine Attacks.
• High blood pressure.
• Cardiac, renal or hepatic insufficiency.
• Heart Disease.
• The Tendency to edema.
• Fibrocystic disease of the breast.

The Presence of all these contraindications and warnings shows that before clarifying the question of how to smear the ‘Divigel” for growth of the endometrium, it is essential to visit a specialist and discuss with him this issue.

Unintended consequences

Every body is different, in its own way perceives the influence of drugs, so even in the absence of contraindications does not mean that will not have side effects. During the treatment gel they can be the following:

1. From the nervous system: headache, dizziness, migraine attacks, depression.
2. The part of the heart and blood vessels: thrombosis and persistent high blood pressure.
3. Digestive system can result in nausea, vomiting, stomach pain and flatulence.
4. Part of the reproductive system can occur: vaginal bleeding, persistent allocation, the growth of the endometrium, change in libido, uterine cancer.
5. Endocrine system may exhibit the following symptoms: the appearance of extra weight, engorgement.

With prolonged use of the gel can occur by the accumulation of fluid in the body, which leads to edema. Given that the drug is used topically, the skin can appear allergic rash, itching.

Some patients who use the ‘Divigel” for growth of the endometrium, reviews leave a negative because of the frequent manifestations of such side effects as blurred vision and strong vaginal candidiasis.

To avoid all unwanted effects to use the drug should be strictly on prescription.

How to take “Divigel” for growth of the endometrium

The Drug if tolerated and no contraindications can be used for long-term therapy. At the initial stage of treatment, the dosage is 1 g of gel. After several courses of the change in the patient, the dosage may be increased or decreased.

It's important to find a doctor not only where to put the ‘Divigel” for growth of the endometrium, but also what day of cycle that we must begin to do.

According to the instructions, the gel should be applied to clean skin in the lower abdomen, lower back, shoulders, forearms or buttocks. To do so, preferably at the same time each day, the area of application should be rotated.

The Most optimal area for applying size is 1-2 palms. The treatment site is not within an hour after using the gel wash.

If a woman forgets to apply the gel, it should be done no later than 12 hours after application of the drug on schedule. If it's been longer then was necessary to postpone it until the next time.

If the dose is exceeded

Many believe that if you take the drug in larger doses, the onset of a positive effect will happen faster, but it is not so. In violation of doctor's recommendations on the use of “Devices” and the excess of the dosage may experience the following symptoms:

• Pain in the chest.
• Bloating.
• The Emergence of feelings of anxiety.
• Irritability.
• Nausea.
• Vomiting.

If any of these symptoms, it is necessary to discuss with your doctor and change the dosage or stop using the drug.

“Divigel” in combination with other tools

If the doctor prescribes the ‘Divigel”, we must inquire whatmedications taken by the patient. Estradiol can exert the following effects:

• To Increase the effectiveness of lipid-lowering drugs.
• Weaken the effect of the drugs, which include male sex hormones.
• Weaken the effect of drugs used in diabetes.
• Reduce the effectiveness of drugs against hypertension.
• Weaken the therapeutic effect of anticoagulants.

Accelerates the metabolism of estradiol joint reception:

• Barbiturates.
• Narcotic analgesics.
• Tools used for anesthesia.
• Some antiepileptic drugs.

The Effectiveness of «Devices” will be significantly reduced if it is used together with some antibiotics, as well as with ‘Phenylbutazone”. To enhance the effect, you can work together with him to take medication folic acid, and thyroid.

Special considerations

“Divigel” for growth of the endometrium the doctors gets more positive, but experts recommend to appoint him after a thorough examination of the patient and detailed conversation with her.

To avoid unwanted consequences, a woman must undergo a full examination of the pelvic organs and breast. It must be regularly and throughout treatment.

We looked at the ‘Divigel” for growth of the endometrium where to put in which area. It is important then to wash your hands with soap and not to touch the eye.

Do Not apply the gel on the area of the breast and gonads, as well as on the places where there is irritation. The use of “Devices” can disrupt the process of ovulation. Synthesis of hormones depends on concentration of estrogen in the blood, and when they come from the outside, it can be broken, why take a drug when you are planning conception should with extreme caution.

Drug Use during pregnancy and lactation

Despite the ‘Divigel” for growth of the endometrium feedback when EKO gets a good, if pregnancy should discuss tactics to further its use with your doctor. If the diagnosis of an interesting situation the woman is not in doubt, it is likely that the doctor will make the decision about discontinuing use of the drug.

Various studies show that occasional and casual use of the gel during pregnancy does not cause teratogenic effect, but to risk the health of the unborn baby is not worth it.

In the period of breastfeeding to apply the gel is prohibited.

Women's Health is a fragile thing, it can fail at the most inopportune moments of life. Nobody wants to stuff your body with chemical drugs, but there are times when just the essential ‘Divigel” for growth of the endometrium, the reviews, the more it gets perfect. Positively this drug is characterized not only doctors, but patients, especially in menopause.

Not superfluous again to remind you that any treatment should appoint only competent expert, do not take such serious drugs on the advice of a friend or seeing an advertisement on TV. Take care of your health!