The drug "Nolpaza": the Russian equivalent, instructions for use, reviews

“Nolpaza” is a anti-ulcer drug. This tool inhibits the enzyme N⁺/K⁺-Atfazu in gastric parietal cells and thus blocks the final stage of synthesis of hydrochloric acid. As a consequence, the level of stimulated and basal secretion of hydrochloric acid is reduced, regardless of what the nature of the different stimulus. After the drug once ingested in a dosage of twenty milligrams, the influence of pantoprazole is activated during the first hour, and the maximum effect is reached in two or two and a half hours. The drug has no effect on the motility of the gastrointestinal tract. As soon as the medication is discontinued, secretory activity is restored in full after three or four days. Russian counterparts “Nolpaza” will consider in this article.

Form of production, packaging and composition

The Drug is a covered soluble in the intestinal membrane of the pill, color-bright brown-yellow, shape-oval, slightly biconvex, her kink is observed mass, which can be white in color or match the shade of tablets, the surface is rough.

One tablet contains 22,55 mg of pantoprazole sodium sesquihydrate, which corresponds to twenty milligrams of pantoprazole. As auxiliary components are: calcium stearate, mannitol, sorbitol, sodium carbonate anhydrous, crospovidone.

The composition of the shell contains the following elements: povidone, macrogol 6000, hypromellose, talc, Polysorbate-80, sodium lauryl sulfate, dye and propylene glycol, iron oxide yellow (E172), water, titanium dioxide (E171), dispersion Eudragit L30D (a copolymer of ethylacrylate and methacrylic acid in the ratio of one to one, a thirty percent variance).

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In a cardboard bundle are one or two blisters, each of which contains fourteen pills. Russian counterparts “Nolpaza” can be purchased at any pharmacy.

Pharmacokinetics

“Nolpaza” has the following characteristics.

1) In terms of suction.

Active substance pantoprazole is rapidly absorbed from the gastrointestinal tract, the maximum concentration is reached approximately two or two and a half hours after consumption and has a performance of 1.0-1.5 micrograms per milliliter, the highest concentration will be constant, even with repeated use. The bioavailability of the drug is equal to seventy seven percent. Simultaneous administration with food has no influence on the bioavailability, the AUC and maximum concentration. There is only a change of time when the drug begins to act. This confirms to “Nolpaza" instructions for use. According to reviews, the analogs work just as good.

2) In the distribution plan.

The Drug binds to plasma proteins about ninety-eight per cent.

3) From the point of view of metabolism.

Active substance pantoprazole is almost entirely metabolized in the liver. Is an inhibitor of the isozyme CYP2C19.

4) Elimination.

The half-life Period is one hour. Due to the specific nature of the binding of the proton pump of parietal cells and pantoprazole half-life period is not correlated with the duration of therapeutic effect. Metabolites are excreted principally through the kidneys (eighty percent), the rest – with bile. The major metabolite, which is determined in urine and blood serum, desmethyldonepezil. He anywhereelse sulfate. The half-life of desmethylastemizole – about one and a half hours, that is greater than that of pantoprazole. The Russian counterparts to the “Nolpaza” should choose the doctor.

The Pharmacokinetics in specific clinical instances

If the patient has renal failure in the chronic form (including those on hemodialysis), any change of dosage of the drug is required. The half-life is short, and for people with good health. During dialysis the excretion of pantoprazole can be performed in a very small volume.

In patients with a diagnosis of "cirrhosis" during the reception of pantoprazole at twenty milligrams per day the half-life increases to three to six hours, and AUC is increased three to five times, and the highest concentration increases of 1.3 compared with healthy individuals.

Are Not clinically significant small increase in maximum concentration and AUC in elderly patients in comparison with the same data from younger patients.

What's more, according to the drug “Nolpaza" instructions for use. The Russian counterparts will be discussed below.

When used drug?

“Nolpaza” recommended for use:

• Gastroesophageal reflux disease (GERD) including symptoms associated with GERD (regurgitation of acidic, heartburn, pain during swallowing), and erosive-ulcerative reflux-esophagitis;
• Ulcerative and erosive defects of the duodenum and stomach, which are caused by use of NSAIDs;
• Eradication of Helicobacter pylori in combination with two antibiotics;
• Peptic ulcer disease duodenalintestines and stomach, prevention and treatment;
• The syndrome of zollingerellison and other pathological conditions associated with increased secretion of the stomach.

In all these cases, doctors prescribe “Nolpaza”. Instructions for use to the Russian analogs contains the same statement.

Who should not use?

Contraindications to the use of “Nolpaza” are:

• Indigestion with neurotic origin;
• The age of eighteen years, since not studied the efficacy and safety of use;
• High sensitivity to the main ingredient pantoprazole or to other components of the drug.

“Nolpaza” contains sorbitol, therefore patients with rare hereditary fructose intolerance, this medicinal product is not recommended.

Caution should be used pregnant women and nursing mothers with liver failure, the risk of developing a deficiency of cyanocobalamin (especially when ahlo and hypogeae).

Russian counterparts cheaper than ‘Nolpaza” relatively easy to find.

Dosage

The Drug is applied inside. Swallow the tablet whole, break, or chew. To drink a small volume of liquid. To eat before eating, often before Breakfast. If the reception twice, the second dose is recommended to drink before dinner.

If the patient – GERD, including associated symptoms in a mild degree, and erosive-ulcerative reflux-esophagitis, it is recommended to take twenty milligrams a day, with moderate or severe degree – from forty to eighty milligrams per day. Relief of symptoms occurs most often in a period of two to four weeks. Therapeutic course lasts from four to eight weeks.

Prophylactic administration

As a preventive measure, as well as long-term maintenance therapy, “Nolpaza” you should drink at twenty milligrams a day, if needed, the dose is increased, the maximum – to eighty milligrams per day. The drug also can be accepted “on demand”, if symptoms occur.

For the therapy and prophylaxis of ulcers of the duodenum and stomach are assigned from forty to eighty milligrams per day. Treatment on the background of aggravation of the duodenal ulcer is predominantly for two weeks, gastric ulcer – from four to eight weeks. If necessary, the duration of therapy increases. This describes to the drug “Nolpaza” instructions. Price counterparts depends on the region and pharmacy chains.

For the implementation of the eradication of Helicobacter pylori in combination with antibiotics it is recommended to take “Nolpaza” in the dose is forty milligrams, twice a day, combining with other drugs. Most often, the course of H. pylori treatment is from seven to fourteen days.

In the presence of the patient syndrome of zollingerellison and other pathological conditions caused by increased secretion of the stomach, the starting dose during prolonged therapy equal to eighty milligrams per day. It is divided into two steps. Thereafter, the daily dose may Mitrovitsa that is determined by the initial level of gastric secretion. The daily dose may be temporarily increased to one hundred and sixty milligrams, if the challenge is to adequately control gastric secretion. The duration of therapy is considered on an individual basis.

For patients with severe disorders of liver function, the dose should not be more than forty milligrams per day is also recommended to continuously monitor the activity of liver enzymes, especially during prolonged treatment with pantoprazole. If the activity of liver enzymes increases, the drug should be avoided.

Elderly patients and those who have kidney disease can make the remedy in a dose equal to forty milligrams.

Elderly people who receive eradication treatment of Helicobacter pylori, it is generally recommended not more than seven days of “Nolpaza”. Analogues are often prescribed the same pattern.

Side effects

Side effects from taking “Nolpaza”.

• The Organs of hematopoiesis: rarely-thrombocytopenia, leukopenia.
• Digestive system: often-pain in the abdomen, constipation, diarrhoea, flatulence; infrequently-vomiting and nausea; rarely – feeling of dryness in the mouth; very rarely-increased activity of transaminases and GGT of the liver, severe damage to this organ, leading to jaundice with liver failure or without.
• Immune system: in very rare cases-anaphylactic reactions, including anaphylactic shock.
• Musculoskeletal system: rarely-arthralgia; myalgia – very rare.
• Central nervous system and peripheral nervous system: often-pain of the head; rarely – visual disturbances (blurring), dizziness, and in very rare cases – a depression.
• Genito-Urinary system: in exceptional cases – interstitial nephritis.
• Allergic Reactions: rarely-rash and itching; very rarely-urticaria, Stevens-Johnson syndrome, photosensitivity, erythema multiforme orLyell's syndrome, angioedema.
• Other: in very rare cases-weakness, peripheral edema, painful tension in the mammary glands, hyperthermia, increased triglyceridemia level.

If you develop serious negative effects, the drug treatment should be immediately discontinued.

The Drug costs about 180-200 rubles per pack. It depends on the region and pharmacy chains.

Russian counterparts “Nolpaza”

On the active substance structural analogues of the “Nolpaza” yavlyayutsya:

• «Sipuncula»;
• «Created»;
• «Panam»;
• «Controloc»;
• «Pants»;
• «Pagenum-sanovel»;
• «Peptazol»;
• «Sampras»;
• «Polare»;
• «Ultra».

«Berita»

The cost of the drug is 380-400 rubles. Is a quality analogue of "Nolpaza" tablets. The predominant connecting rabeprazol is characterized by a pronounced antiulcerous antisecretory effect. Can be administered for the treatment of digestive pathologies of ulcerative nature. Forbidden to receive during pregnancy, breastfeeding, allergies.

“Gastrozol”

Is 130–140 rubles. It's a cheap Russian equivalent of “Nolpaza”. Available in capsules oblong. The main component of omeprazole has intezmeny effect. Prescribed for the prevention and treatment of gastric ulcers. Restrictions to receive the same.

“Premier Finance”

Quite expensive - 800-850 rubles.

But he is considered the best prototype of the original Russian manufacturers. Effective for ulcers and gastritis. It is not recommended during pregnancy, lactation, for children.

We reviewed the key counterparts “Nolpaza”.

Reviews

Patients have to say about the use of “Nolpaza” and analogues of both positively and negatively.

Among the advantages of drugs stand out: speed and efficiency, elimination of pain in the stomach, help in correcting the effects of errors of diet, ease of administration (only one tablet a day). Many patients thanks to the use of “Nolpaza” did not require complex treatment.

Among the disadvantages special emphasis on patients doing a large number of side effects. In addition, it is noted that the drug is not expensive. However, in this case one should choose the drug individually to suit not only price, but also suit the body and cause negative reactions.

We reviewed in the article for the tool, “Nolpaza” the instruction, reviews, analogs.