"Panangin": reviews, instruction, analogues

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2019-01-09 08:00:41

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“Panangin” is a drug that affects metabolism. It supplies magnesium ions, and potassium. Reviews about ‘Panangin” will consider in this article. The drug is available in the following forms.

  • Tablet with a film cover, color – almost white or white. In the form of a lenticular, round, with uneven and slightly shiny surface and is virtually odorless.

One tablet contains 166,3 mg hemihydrate potassium Asparaginate, 175 mg of the tetrahydrate of the magnesium Asparaginate. Auxiliary components: 2 mg of colloidal silicon dioxide, 3.3 mg of povidone K30, 4 mg of magnesium stearate, 10 mg of talc, 86,1 mg of corn starch, 3.3 mg of potato starch.

Panangin manual reviews

In carton packs from polypropylene bottles of 50 tablets.

  • A Solution for intravenous introduction colorless or pale green, transparent, visible mechanical inclusions do not exist.

In one ampoule and 45.2 mg of potassium asparaginata (hemihydrate form), 40 mg of Asparaginate magnesium (tetrahydrate form). Excipient: 10 ml water for injection.

Ampoules made of colourless glass (10 ml), five pieces in pallets, plastic, carton packaging.

Reviews of ‘Panangin” abound.

Pharmacological effect

A Drug that affects metabolism. Is a source of magnesium ions and potassium, which are intracellular cations, which play a key role in the activities of many enzymes in the formation of links between intracellular structures and macromolecules in the mechanism of muscle contractility.

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The extra - and intracellular ratio of sodium ions, calcium, magnesium and potassium affects the ability of the myocardium to contract. Endogenous aspartate affects both the conductor ions: it has high cell affinity, due to the small dissociation of its salts ions in the form of complex compounds fall into the inner part of the cell. Magnesium and potassium aspartate helps to improve metabolic processes in the myocardium. Deficiency of magnesium ions and/or potassium predisposes to the formation of atherosclerosis of the coronary arteries, arterial hypertension and the occurrence of metabolic transformations in the myocardium.

Among the most significant physiological functions of potassium is maintaining the potential of the membranes of the myocytes, neurons and other excitable tissue structures of the myocardium. Violation of the ratio between extra - and intracellular presence of potassium leads to a decrease in myocardial contractility, tachycardia, arrhythmia and increased toxicity of the glycosides of the heart.

Panangin application reviews

Magnesium is a significant co-factor in over three hundred enzymatic reactions, including synthesis and energy metabolism of nucleic acids and proteins. In addition, magnesium is of great value in cardiac activity: increases heart rate and contractility, leading to lower oxygen demand of the myocardium. Mizitova decrease contractility of smooth muscle walls of arterioles, including coronary, causes vasodilation and increased coronary blood flow intensity. Thanks to the magnesium on myocardial tissue is antiischemic effect.

The Combination of magnesium ions and potassium in one medicinal product is justified by the fact that the lack of potassium in the human body and is also often accompanied by magnesium deficiency, requiring simultaneous adjustment of the contents of both ions. If the correction of electrolyte levels is carried out simultaneously, there was an additive effect (a reduced degree of magnesium and/or potassium has proaritmogenny effect). Also magnesium and potassium reduce the toxicity of the glycosides of the heart, without affecting their positive inotropic effect.

Reviews of the app “Panangin” will be presented at the end of the article.

Panangin reviews of cardiology

Pharmacokinetics

The Feature of suction during the internal consumption of the drug high absorption. It is excreted along with urine. Information about the pharmacokinetics of this drug in an intravenous solution does not exist.

Readings

“Panangin” is used:

  • As part of complex therapy of heart failure, myocardial infarction in the acute form, cardiac arrhythmias (mainly ventricular arrhythmias and is caused by overdose of cardiac glycosides body);
  • To make up for lack of magnesium and potassium by reducing the content of their food in the human diet (pill);
  • To improve the portability of cardiac glycosides.

This is confirmed to “Pananginum” instruction and reviews of cardiology.

Panangin manual reviews of cardiology

Contraindications

The Drug is forbidden to take inside:

  • In chronic and acute renal failure;
  • If gipermagniemii;
  • AV-blockade of I to III degree;
  • Hyperkalemia;
  • If Addison's disease;
  • In severe myasthenia gravis;
  • In cardiogenic shock (blood pressure below 90 mm Hg. century)
  • When hemolysis;
  • Defectsamino acid metabolism;
  • In metabolic acidosis the acute form;
  • When dehydration of the human body.

Should be used with caution during pregnancy (especially first trimester) and breastfeeding.

Not administered intravenously in such cases:

  • Chronic and acute renal failure;
  • Hyperkalemia;
  • Addison's disease;
  • Hypermagnesemia;
  • AV-block II to III degree;
  • Myasthenia gravis, severe;
  • Cardiogenic shock;
  • Dehydration;
  • Deficiency of the adrenal cortex;
  • Safety and efficacy not determined in the use of minor patients;
  • Pregnancy;
  • Lactation period;
  • Excessive sensitivity to the composition of the drug.
Panangin Forte manual reviews

Should be used cautiously in the presence of first degree AV-blockade, severe defects in the functioning of the liver, disorders of metabolism, the probability of occurrence of edema, defects of the kidneys, if it is impossible to conduct a permanent monitoring presence in the blood serum of magnesium (risk of formation of accumulation, toxic magnesium content), urolithic diathesis, and hypophosphatemia, which are associated with failure of exchange of ammonium phosphate, magnesium and calcium.

Feedback about the use of “Panangin”.

Dosage

Tablets, taken by mouth: discharged one or two pills (a day – three times). The daily maximum dose-three tablets at a time. The drug should be taken after eating as the acidic environment of the gastric contents reduces its effectiveness.

The Duration of the treatment course and re-appointment are determined by the doctor individually.

Intravenous drip, the drug is indicated, in the form of a slow infusion (per minute – twenty drops). If necessary may be repeated after 4-6 hours.

To prepare a solution for intravenous infusion, one or two of the vial is dissolved in 50-100 milliliters of a solution of glucose (dextrose) concentration of five percent.

The Drug may be used for the combined treatment.

Panangin reviews analogues

Side effects

According to the feedback on “Panangin" ingesting it can be observed the following side effects:

  • A system of vessels and heart: there may be paradoxical reaction (increased number of extrasystoles), AV-blockade;
  • Digestive system: diarrhea, vomiting, nausea, burning sensation and discomfort in the area below the stomach (in patients with cholecystitis and gastritis);
  • The balance of water and electrolytes: hyperkalemia (paresthesia, diarrhea, vomiting, nausea), hypermagnesemia (the feeling of thirst, redness of the skin, reducing AD, the suppression of breathing, hyporeflexia, convulsions).

Intravenous administration also has a number of side effects: if administered quickly, can be signs of hyperkalemia (myasthenia gravis, fatigue, confusion, paresthesia, arrhythmias, cardiac arrest, arrhythmia) and gipermagniemii (decrease neuromuscular excitability, vomiting and the urge to her, lethargy, decrease in blood pressure). In addition, we can develop phlebitis, paradoxical reaction and AV-blockade (increase in the content of extrasystoles).

All this is confirmed by instruction and feedback.

“Panangin Forte” has exactly the same side effects.

Counterparts

“Panangin” has the following structural analogues: “Asparkam”, “Payton”, “Asparkam-L”, asparaginat magnesium and potassium “Berlin-Chemie”, “Asparkam-firm”, “Asparkam-UBF”.

user testimonials

Feedback on “Panangin”

The Reviews about the drug in the majority of cases positive. It helps to prevent heart attacks, eliminates heaviness, discomfort, and improves overall well-being.

Of the shortcomings observed only dizziness and weakness, in some cases, nausea. Very caution should appoint patients with low blood pressure or reduced heart rate.

Also here are reviews of cardiology on “Panangin”

The experts

The opinions of experts about this drug also positive. However, some cardiologists believe it ‘dummy”. That is, in their opinion, no serious abnormalities with the heart to take it there is no need, as in the case of severe health problems this drug simply will not help.

We looked to the drug “Panangin” instructions and feedback.

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