Treatment of hypertension and heart failure has become possible since the discovery of angiotensin-converting enzyme inhibitors. One of the representatives of this group from the substance captopril. Preparations on its basis is widely used to reduce high blood pressure and relieve hypertension.
The Cure “Captures” refers to the comprehensive funds, which has two active substances: captopril & ndash; angiotensin-converting enzyme inhibitor and a diuretic hydrochlorothiazide. The drug has a marked hypotensive and diuretic effects. It is manufactured in tablet form for oral administration of the Ukrainian pharmaceutical firm "Darnitsa".
There are two dosages of the drug, wherein the amount of the diuretic component. Blood pressure pills “Captures” contains 50 mg captopril and hydrochlorothiazide 25 or 12.5 mg. Additional ingredients are povidone, milk sugar, Aerosil, potato starch and magnesium stearate.
The drug “Captures” the price ranges from 180 rubles per pack. The cost is much lower than other alternative medicines, reducing the pressure that does not reduce its effectiveness. In the country of origin on medicine “Captures” the price is about 89 rubles per pack of 20 tablets.
Active components determine the mechanism of action of the drug “Captures”, which determines its therapeutic effect on the human body.
Due to the inhibition of angiotensin converting enzyme by captopril is the suppression of synthesis of angiotensin of the 2nd type. Under the action of the Oligopeptide hormone that constricts blood vessels, stimulates the production of aldosterone by the adrenal cortex.
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The Reduction of angiotensin the second type reduces the pressure in the arteries, in the right atrium, the blood vessels, forming a small circle of blood circulation, total peripheral vascular resistance, the load on the heart muscle. Knowing the characteristics of captopril, it is possible to determine the effect of the drug “Captures” where the pressure to adopt the medication.
Thanks hydrochlorothiazide is a moderate diuretic influence on the urinary system due to removal of water molecules, chloride, potassium and sodium ions from the body. The substance is able to reduce the level of sodium in the vascular wall, making it less sensitive to the vasoconstrictor effect, and to increase the antihypertensive effect of captopril.
The Drug removes arterial hypertension in different forms, including resistant to other drugs hypertension.
With this tool, carry out emergency aid during hypertensive crisis.
To the medication helped, it should be drunk only after pressure measurement.
It is Important to know when to take pill “Captures”. Indications for use of the drug include:
The Drug is used for emergency care at hypertensive crisis.
You Have to be very careful with tablets “Captures”. Under any pressure to take medication in order not to harm health? This question is asked by many patients with hypertension your doctor.
Typically, normal pressure is considered 120/80 mm Hg. article higher values you need to take steps to decrease in blood pressure. If patients assigned to the drug “Captures” from the pressure, it should drink 60 minutes before meals, so as not to violate the absorption of active ingredients.
the Dosage is adjusted depending on the form of hypertension and the severity of each patient individually.
Treatment should Begin with half a tablet, which contains captopril 25 mg and hydrochlorothiazide 12.5 mg. drink It 1 time a day. For further supportive therapy take a day for a whole tablet with the amount of captopril 50 mg and hydrochlorothiazide 25 mg. the Maximal therapeutic effect observed after 1.5-2 months from first use. Adjustment to the dosing is carried out using 6-week interval, given the lack of demand for its rapid change.
The Lack of a decrease in bloodpressure can be a reason for inclusion in the treatment of additional quantities of captopril and hydrochlorothiazide, which take in the composition of single-component drugs. The number of daily doses of captopril should be no more than 150 mg, and the content of hydrochlorothiazide – not more than 50 mg.
For the relief of hypertensive crisis use one tablet that is chewed and held under the tongue.
Excretion of captopril and hydrochlorothiazide is done with the help of the kidneys. Disturbances in this organ (creatinine clearance of 30-80 ml for 1 minute) lead to higher levels of the active components of tablets in the serum.
To adjust the dose of active ingredients to the therapeutic indicators, take a day, all right, which corresponds to the number of captopril 25 mg and hydrochlorothiazide 12.5 mg. Usually take medication in the morning 1 hour before Breakfast.
Tablets “Captures” treat hypertension and heart failure, and their main component of captopril was first used in the 70-ies of the last century. Many patients talking about the benefits of the drug, what with it quickly decreases blood pressure during hypertensive crisis. It is important to properly and regularly take pills to get effective results.
In the course of numerous clinical trials based on captopril, it has been proven that they lower blood pressure and reduce the number of deaths from diseases of the cardiovascular system.
The drug “Captures” instruction manual includes a number of contraindications, which include increased individual sensitivity to the active substances of tablets, angiotensin converting enzyme inhibitors and sulfa derivative.
Do Not take the drug stenosis of the artery going to one kidney or two kidneys after the transplant, this organ, in severe violations in his work, when the rate of blood clearance from creatinine clearance is 30 ml for 1 minute, and its concentration in the plasma does not exceed 1.8 mg per 100 ml.
The Drug is not used in patients who have signs of primary hyperaldosteronism, reduced level of potassium and sodium ions in blood, hypovolemia, gout and hypercalcemia obstructive changes with stenosis Ortego mouth and with impaired outflow of blood located in the left ventricle.
the Banned drug during a severe liver disease, pregnant and lactating women. Contraindication is the children's age of 18.
Diuretics stop taking 3 days prior to the first use of the drug on the basis of captopril and a diuretic.
Special care require elderly drivers, immunocompromised patients whose creatinine clearance is 30-60 ml per 1 minute, in the urine elevated protein content and its performance exceed 1000 mg per day.
You Have to be very careful when taking procainamide, heart failure, impaired renal function, diabetes, increased pressure in the renal arteries. To monitor the health of the patient is usually prescribed periodic pressure measurement, a check of renal function and the level of electrolytic ions of blood.
While taking the drug “Captures" the manual describes the appearance in some patients, various adverse reactions, which affect different systems of the body.
With a negative impact on the digestive tract and liver, decreased appetite, mucous membrane of the mouth becomes dry, it can be observed nausea, vomiting, pain in stomach, irregular bowel movements, the development of stomatitis, peptic ulcers, jaundiced condition, hepatitis, increased bilirubin in the blood.
The Effect on the heart, blood vessels and organs of hematopoiesis may manifest tachycardia, angina, lowering the pressure, Raynaud's syndrome, redness or paleness of the skin, cardiogenic shock, neutropenia, agranulocytosis, thrombocytopenia, pancytopenia, hemolytic anemia or aplastic form.
On the Central nervous system drug has an effect that violate the the sleep, sight and taste sensations, cerebral blood flow, causing headaches, dizziness, emotional lability, confusion, numbness of the extremities.
On the respiratory system the effect is manifested by cough, impaired respiratory system, bronchospasm, and allergic rhinitis.
Side effects on the urinary system are expressed renal failure, polyuria, oliguria, nephrotic syndrome.
You May develop allergies as skin rashes, itching, hives, angioedema, Stevens-Johnson syndrome, photosensitivity, erythema.
For many patients it is important to know how the drug “Captures” at what pressure to take it. Usually drink medicine when increased blood pressure that is not correct. Need systemic administration of medication according to doctor's recommendations.
In the course of treatment, you should check electrolyte concentration, particularly potassium ions, the amount of creatinine and urea, and monitor blood counts peripheral parts.
While taking the drug needto use products with minimum contents of sodium, are contraindicated alcohol.
Possessing diuretic effect, medication can aggravate the condition of disturbed water and electrolyte balance, associated with diuretic therapy, diarrhea, vomiting, diet with low sodium, hemodialysis, resulting in the development of hypotension. Prior to antihypertensive therapy should be adjusted electrolytes in the body.
Patients with compromised cardiac activity and older people with care assigned tablets “Captures”. Under any pressure to take the drug so that its performance does not become too low? Before taking medication you should check blood pressure, it is also necessary to monitor kidney function, the content of vitally important ions.
The Negroid race is considered to be resistant to the effects of drugs inhibiting angiotensin converting enzyme, captopril therefore has a smaller effect on these patients.
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