Methotrexate. Usage instructions

The Drug Methotrexate is an antitumor agent. The drug included in the group of antimetabolites – antagonists of folic acid. The drug Methotrexate is active against rapidly growing cells. In addition, the drug is able to exert some immunosuppressive effects.

Methotrexate. The instructions for use. Statements.

The Drug is prescribed for acute lymphocytic leukemia, Ewing's sarcoma, and osteogenic magallona, retinoblastoma, germ cell tumors of ovary and testis, trophoblastic disease, medulloblastoma. Methotrexate instructions for use recommends the use and cancer of the vulva and cervix, skin, esophagus, renal pelvis and ureter, breast, lung, kidney, liver, penis, squamous cell of head and neck, as well as with chlamydia. The drug is indicated for psoriasis and rheumatoid arthritis severe forms of the currents in the absence of therapeutic results from the apply adequate therapy.

Methotrexate. The instructions for use.

The Drug is designed for intravenous, oral, intramuscular intralumbalno and use. The dosage regimen set individually the patient. The doctor takes into account the characteristics of the pathology, the state of the hematopoietic system, the scheme of cancer treatment.

The use of the drug can cause anorexia, stomatitis (ulcer), gingivitis, nausea, pharyngitis. In rare cases enteritis, diarrhoea, pancreatitis, melena. Continued daily use may in some cases cause cirrhosis, necrosis in the liver, fatty atrophy, fibrosis of the liver periportally.

Adverse reactions when using the drug "Methotrexate"  instructions for use include anemia, leukopenia, dizziness, fatigue, thrombocytopenia, aphasia, convulsions, headache, somnolence.

In some cases, it may be a disorder of the menstrual cycle, spermatogenesis, oligospermia, impotence, decreased libido.

Some patients Have noted cystitis, hematuria, disorders of renal function defined character, lowering resistance to infection, chills, urticaria, toxic epidermal necrolysis, photosensitivity, rashes, boils, acne, telangiectasia.

Contraindicated Methotrexate leukopenia, pregnancy, disorders of activities of liver and kidney Express. Not recommended means and with immunodeficiency. If you need to take medication during lactation, feeding should be stopped. As a result, some studies have demonstrated teratogenic and embryotoxic effects.

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Women of reproductive age should use reliable contraception when using "Methotrexate".

Not recommended a medicine for peptic ulcer in the duodenum and the stomach, pleural effusion, ascites, kidney disease, gout, colitis (ulcerative).

Patients with chickenpox currently or recently transferred, herpes (zoster) and other infectious diseases acute of Methotrexate is not assigned.

Before the treatment on the background of applied therapy is necessary to control blood picture (peripheral), the kidneys and the liver.

The use of Methotrexate in rheumatoid arthritis or psoriasis are required to conduct a General analysis of blood (gallery) at least once a month, laboratory tests of liver function, kidneys – at least once in a month or two months.

Before the appointment the patient should be apprised of all alleged adverse events. Methotrexate is a serious medication. In order to avoid undesirable complications the use of medication should be monitored by a doctor.