Levonorgestrel: this hormone and what does it do in the body?

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2018-03-24 09:10:15

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Many people wonder: levonorgestrel - what is this hormone? It is a synthetic progestogen which converts the endometrium, minimizing the ovulation, preventing the fertilization of an egg prepared. In addition, with the help of the receptors of the mucous membranes get reduced sensitivity. In this article, we consider a product containing a hormone called. levonorgestrel what is the hormone

Pharmacology

Drug "Levonorgestrel" – estrogen, preventing the activation of spermatozoa due to an increase in viscous properties of mucus. The drug inside the uterus locally affects the fallopian tubes, the endometrium, the consistency of mucus, resulting in follicle-stimulating hormone reduces its activity.

When used inside the called drug is actively absorbed in the intestine, biopolitical up to 100%. Blood components concentrate in the intake of 75 ml of one-time 60 - 130 minutes. Consider the hormone interacts with the plasma binding globulin components by about 50%.

Metabolism is focused on the liver, thus formed pharmacologically passive metabolite. The main isoenzyme of this hormone is CYP3A4. The term half-life can last up to 30 hours.

Properties

In answer to the question "Levonorgestrel - what is this hormone?" should be guided by the instruction to the same drug and recommendations of the attending doctor. Indicators of the difference in the total value are in the order of 1.0 ml/min/kg (plasma). The hormone is mainly eliminated via the ureter, a small part is removed with the stool.

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In the treatment of a systemic nature speed characteristics entering the uterus not exceed 20 mcg daily, and in five years, falling to 11. The average rate of output of the hormone varies in the region of 14 µg/24 h for 50-60 months.

Intrauterine therapy allowed for women with a substitute hormone treatment in conjunction with estrogen, progestin does not include composition. Levonorgestrel – is a hormone, which penetrate into the plasma 60 minutes after ingestion. The maximum concentration in it is recorded after 14 days of use.

the hormone levonorgestrel action

Readings

The Use of this drug for intrauterine therapy, and in the following cases:

  • Menorrhagia idiopathic orientation.
  • Long contraceptive protection.
  • Preventive measures with replacement restore using estrogen.
  • Emergency postcoital contraception.

The Hormone levonorgestrel, which has a vast scope, it should be used only after doctor's recommendation.

Usage and dosage

Consider the drug is activated by intrauterine injection is injected into the uterine cavity. Used for 4 days after copulation, in the amount of from 0.75 to 1.5 mg Emergency contraception, experts strongly suggest to practice more than once every six months.

To avoid disruption of the menstrual cycle, it is necessary to observe the recommended dosage without re-use. You cannot use the considered the drug orally as a method of permanent contraception as it provokes the emergence of side effects and reduces the effectiveness of the medication. In the case of uterine krovoobrashseniya after emergency contraception is strongly recommended for the procedure of examination by a gynecologist, and in violation of menopause more than one week you need to postpone the conception.

Only after counseling and informed decision gynecologist in extraordinary cases it is allowed the use of the drug for contraception in minors during emergency.

the hormone levonorgestrel effect on the body

How is the hormone levonorgestrel?

What is the impact on the body described the use of the hormone and what to do to avoid side effects? This question is raised by many. Strict compliance with the recommendations of a specialist, compliance with dosing and follow instructions – safe use of the drug.

Before using the IUD, you will undergo a gynecological examination, including checking the mammary glands, pelvic, a PAP smear of the cervix.

Re-examination is carried out after 30-40 days after installation of the helix, then annually, and in case you have the appropriate prerequisites more often. This intrauterine therapy is effective for 4 to 5 years. It must deal exclusively with a doctor who specializes in this field or having experience to the sort of the drug.

Risks

Women taking medicines with progestogen, does not exclude the increase of venous thrombosis in the critical moment. When such symptoms should immediately take urgent measures to diagnosis and treatment.

After the withdrawal IUD fertility resuscitated after six months half of the women who applied, after 12 months — more than 96 percent. The focus of the contraceptive less effective for obese patients.

 levonorgestrel is the estrogen

Contraindications

Asking "Levonorgestrel - what is this hormone?" you should examine all contraindications. Amongthem:

  • Over(Hyper)sensitivity, tromboflebite education.
  • Thromboembolism, the change in the arteries.
  • Cerebrovascular Disease orientation, pregnancy.
  • Regarding ingestion: jaundice (including in history), pathological complications output of bile or liver disease, lactation.
  • Maturity.
  • In addition, for the Navy — infections of the genitourinary site, the relapse or active inflammation in the pelvis, the excesses of postpartum endometritis, acute liver disease.
  • Septico-abortive intervention in the last trimester, cisplatine the transformation of the uterine cervix, pathology with a similar bleeding of unclear origin, malignancy.
  • Who have congenital anomalies, distorting fibroids.
  • Progestagens (tumor, including a cancerous breast lesion).

levonorgestrel is a female hormone

Limitations

The limiting factor is often relevant for therapeutic intervention inside the uterus, if there are to be any of the following symptoms or chronic diseases.

  • Headaches, customary and local migraine with blurred vision, other symptoms focused on the possibility of coronary artery disease;
  • Explicit directions arterial hypertension, jaundice, complex, destructive processes in the circulatory system, including heart attacks and strokes;
  • Diabetes mellitus.

You Should immediately consult about the elimination of the Navy in the formation or the presence of any of these conditions.

Pregnancy and lactation period

Despite the fact that levonorgestrel is a female hormone, its use is unacceptable during pregnancy. If it was, recommended the elimination of the system due to the fact that any intrauterine contraception increases the risk of premature birth and miscarriages. Conducting uterine sounding or liquidation of the system sometimes leads to a miscarriage that occurred randomly. Need expert advice on the appropriateness of abortion in incorrect extraction of contraceptive.

In case of impossibility of removal of the intrauterine system and insistence to continue with the pregnancy, the patient should be informed about the possible consequences and risks for the baby due to early birth. In such cases, it is imperative to carefully monitor the pregnancy. To patients should convey the information that she needs to immediately report all symptoms that will suggest a complication process.

levonorgestrel is a hormone

Lactation

Breastfeeding and the use of "Levonorgestrel" about one tenth of the drug enters the body of the baby. Breastfeeding inside for emergency contraception should be discontinued for 1.5 days.

For therapeutic systems intrauterine, as with any progestogen-only method of contraception, characterized by that the application of the six weeks postpartum has a detrimental impact on development and growth of the child thus, the drug likely poses no risk to the fetus when recommended dosage.

Side effects

Returning to the question "Levonorgestrel" what is this?" let's look at the possible side effects and contraindications of the drug. They can occur in different body systems and represent the following symptoms:

  1. From the nervous system: fatigue, depression, headache, mood swings.
  2. Digestive tract. Vomiting, upset, cramps, bloating.
  3. Urogenital organs. Bleeding, discharge, pain, candidiasis, the probability of formation of malignant and benign tumors.
  4. Skin rash, a manifestation of eczema, itch, hives, pimples.
  5. Other: swelling, joint pain, pressure surges, sepsis.

In rare cases, epileptic seizures, convulsions and fainting.

Combination with other drugs

Studying "Levonorgestrel" (that's the hormone), it is necessary to mention the possibility of combining it with other drugs, and organic drugs. In the case of the application of this substance with inducers of cytochrome P450 isoenzymes may reduce efficiency due to increase its metabolic processes.

what is levonorgestrel

Presented below medicines can reduce the effect of "Levonorgestrel"

  • Barbiturates, "Tretinoin", "Carbamazepine", the compositions containing St. John's wort and its Campanario.
  • Reduced effectiveness of anticoagulants, hypoglycemic, anticonvulsant drugs.
  • "Levonorgestrel" increases the capacity of glucocorticoids in the blood and can disrupt metabolism.
  • Due to the inhibition of recirculation of sex steroids, due to the reorganization of the intestinal flora, there may be increased menstrual bleeding with the complex application of certain drugs.

It is important to add, to mention, how is "Levonorgestrel" that this means it causes increased side effects of other medicines, antidote to him there. In case of overdose symptomatic treatment is required.


Article in other languages:

AR: https://tostpost.com/ar/health/829-levonorgestrel-this-hormone-and-what-does-it-do-in-the-body.html

BE: https://tostpost.com/be/zdaro-e/1407-levonorgestrel-shto-geta-za-garmon-za-shto-en-adkazvae-argan-zme.html

DE: https://tostpost.com/de/gesundheit/1404-levonorgestrel-was-ist-das-f-r-ein-hormon-und-was-es-erf-llt-im-k-rper.html

ES: https://tostpost.com/es/la-salud/1409-levonorgestrel-que-es-la-hormona-que-cumple-en-el-organismo.html

HI: https://tostpost.com/hi/health/829-levonorgestrel.html

JA: https://tostpost.com/ja/health/828-levonorgestrel.html

KK: https://tostpost.com/kk/densauly/1407-levonorgestrel-b-l-gormon-sebeb-ol-a-zada-y.html

PL: https://tostpost.com/pl/zdrowie/1410-lewonorgestrel-co-to-za-hormon-i-za-co-on-odpowiada-w-organizmie.html

PT: https://tostpost.com/pt/sa-de/1407-o-levonorgestrel-o-que-esse-horm-nio-e-por-que-ele-est-no-corpo.html

TR: https://tostpost.com/tr/sa-l-k/1413-levonorgestrel-bu-hormon-ve-o-v-cutta-sorumludur.html

UK: https://tostpost.com/uk/zdorov-ya/1409-levonorgestrel-scho-ce-za-gormon-za-scho-v-n-v-dpov-da-v-organ-zm.html

ZH: https://tostpost.com/zh/health/880-levonorgestrel-this-hormone-and-what-does-it-do-in-the-body.html






Alin Trodden - author of the article, editor
"Hi, I'm Alin Trodden. I write texts, read books, and look for impressions. And I'm not bad at telling you about it. I am always happy to participate in interesting projects."

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