"Quinidine": instruction manual, composition, description and reviews

Which requires a tool such as “It”? Instructions for use, price, reviews and the appointment of this drug will be presented below. You will also learn about what pharmacological properties characteristic of this drug, does it effects side character and whether he has any restrictions for use.

Composition, form, description

The form In which a pharmaceutical company produce a medicine “It”? Instructions for use included with the tool States that it can be purchased in the form of flat and round tablets. They have prolonged action and covered with a film cover.

The Main ingredient of this drug is quinidine sulfate. Instructions description of the drug do not give any information on additional substances.

Pharmacy medication

What are the tablets “It”? Instructions for use, description, reviews report that this remedy arrhythmias class IA. It can slow the process of ion transfer through the fast Na channels of cell walls of cardiomyocytes, as well as to reduce the speed limit depolarization and increase the duration of the action potential and refractory (effective) period of time.

Taking this medication reduces the excitability of the myocardium, slows automaticity and conduction in the AV node, the bundle branch block, atrial fibrillation and other structures. Also the tool has wagoliticeski effect is m-holinoblokirutmi effect, reduces the activity (contractility) of the heart muscle and causes a decrease in blood pressure.

Recommended

A tablet from worms – the relevance of the application for the person

How relevant today, drugs against worms in humans? What kind of creatures these worms, what are modern methods of treatment? We will try to answer these questions, since ignorance in this area is undesirable. Imagine a mummy, which is misleading in k...

What to do if you cracked skin on hands?

Each of us at least once in a lifetime encounter with a small, but very, when the crack the skin on the hands. At this time there are wounds of different sizes, which hurt and cause inconvenience, especially when in contact with water or detergents. ...

Spray Macho man - the key to a proper relationship between the two spouses

Male impotence is a pathological condition associated with abnormal physiological capacity of the penis to reginout and bring sexual partner pleasure in bed.sex impotenceimpotence may not men to pass unnoticed – it usually spoils his nervous sy...

Properties medication

What is medication, such as “It”? Instruction manual notes that it can have a negative inotropic effect. This is the result of the slow process of conversion of internal energy in the mitochondria. As for the antiarrhythmic properties of the drug, they are associated with the presence of the molecule of amide groups in the structure of the active substance.

According to the experts, while taking this medication significantly reduced the excitation and the speed of its spread that is due to the effects of the active component of medication on the process of depolarization.

Inhibiting the muscarinic receptors, the drug stimulates the AV-conduction. In therapeutic doses it exhibits hypotensive properties associated with lowering the tone of peripheral veins and arteries, as well as with a negative inotropic effect.

Not to mention the fact that this medication is able to show local irritating effect. He also has analgesic and antipyretic properties, which are associated with a depressing effect on the brain.

Pharmacokinetic features

Absorbed whether such active ingredient of the drug as quinidine sulfate? Instructions for use reports that taking this oral treatment contributes to its greatest concentration in blood after 95 minutes.

The Reaction of the drug with proteins is around 77-80%. Its biotransformation occurs in the liver. However, some of the formed derivatives have a cardiotonic effect.

The half-life of this tool is approximately 7 hours. It is excreted mainly by the kidneys. When acidification of urine secretion of medication is enhanced, and when its alkalinity – is inhibited.

What is prescribed?

What are the indications for use has the drug “It”? Instruction manual says that the purpose of the drug is justified only in the following cases:

• In atrial tachycardia, AV-tachycardia, arrhythmia supraventricular and ventricular seizures flicker and flutter;
• To prevent attacks of tachycardia (ventricular and supraventricular) and ventricular fibrillation;
• After the implementation of cardioversion in order to preserve the rhythm of the sinuses.

Restrictions to the application

What the condition of the patient prohibit the use of the medication “It”? Instructions for use (price of this medication is listed below) reports these contraindications of the drug, such as:

• Shock, cardiogenic;
• AV-block (second or third degree).
• Thrombocytopenic purpura, which developed after taking the medicine;
• Disorders (severe) intraventricular conductivity;
• The blockade of bundle branch block;
• Intoxication glycosides, which is accompanied by violation of conductivity;
• An allergic reaction to the drug;
• Myasthenia gravis.

Medication “It”: application manual

To Adopt the tool should be inside for 60 minutes before or after 125 minutes after a meal with a full glass of water. If you want to reduce the irritant effect of the drug on the mucous membrane of the digestive tract, water should replace milk.

The Drug prolonged action do not chew or crush.

Consider the Standard dosage of tablets is 200–300 mg four times a day. When supraventriculartachycardia (during the paroxysms) this number increase to 400–600 mg every 3 hours until complete relief of the paroxysm. In atrial fibrillation medicine take 200 mg every 2 hours (5–8 times per day). When this maintenance dose is 200–300 mg four times per day.

Alternative regimen: 400 mg (if the attack was not docked, then 200 mg) every 60 minutes until the end of attack or until the total dose of 1 g.

In the absence of side effects after the first dose subsequent admission number of medication should be increased to 600 mg Take the drug more than 4 grams per day is prohibited.

Method of application for children

In what dose is prescribed to children drug “Quinidine Durules”? Usage instructions reviews of pediatricians say that the standard dosage of this means for kids is 6 mg/kg 5 times a day. To prescribe medication should only experienced doctor strictly indicated.

Effects side nature

Some adverse effects may occur after you use the medication “the Quinidine Durules”? Instructions for use, description of this drug say about the following adverse reactions:

• Fatigue, expansion of the QRS segment, myasthenia gravis;
• Ectopic ventricular arrythmia, hearing loss;
• Loss of appetite, ventricular fibrillation, arterial thromboembolism, decrease in blood pressure;
• Blurred vision, ventricular tachycardia, paroxysmal, ringing in the ears
• Asystole;
• Nausea, sinus bradycardia, hepatitis, pain in the abdomen, confusion;
• Gastralgia, headache, vomiting, thrombocytopenia, diarrhea, dizziness, haemolytic anaemia;
• Fever, volchanochnopodobny syndrome, skin rash.

Overdoses

What are the symptoms of an overdose can cause the drug “Quinidine Durules”? Manual, reviews of experts say about such problems as ringing in the ears, depression of cardiac performance, decreasing blood pressure, dizziness, atrial flutter, diplopia, hinidinovy shock, hearing loss.

To eliminate such conditions to the victim appoint gastric lavage, oxygen, hypertensive drugs, cardiac pacing, renal dialysis and a ventilator.

Drug interactions

How the drug interacts with such a substance as quinine? Instructions for use (price, drug will be presented at end of article) reports that this combination increases the toxicity of both funds.

Also, tablets “It’ interact with the following medications:

• Antiarrhythmic drugs increase cardiodepressivne action.
• Anticholinesterase drugs and potassium-containing medications enhance the effect of “Quinidine’.
• Anti-seizure medicines reduce the amount of “Quinidine” in the blood and reduce its efficiency due to the stimulation of its metabolism.
• Laxatives to reduce the effectiveness and concentration of the considered chemical in the blood.
• Medicines alkalizers urine, increases the risk of toxic reactions.
• Drugs ‘Amiloride” and “Sense” to reduce the effectiveness of “Quinidine” and extend his period of QT, respectively.
• Acetylsalicylic acid prolongs bleeding, promotes petechiae and bleeding from the digestive system.
• Drugs "Warfarin" and "Isoptin" - increases anticoagulant effect of the first and decreases the rate of excretion of the second.
• Drug “Haloperidol” - increased its content in blood and increases the risk of adverse reactions.
• Drugs "Hydroxyzine” and “Dextromethorphan” - increases the likelihood of severe arrhythmias during the first and blood second.

Special information

With extreme caution described the cure recommended for chronic heart failure of stage 2-3, tachyarrhythmia (ventricular) with elongation of the segment QT, sick sinus, AV-blockade of 1st degree, bronchial asthma, hyperthyroidism, hypotension, acute infectious diseases, emphysema, angle-closure glaucoma, hypokalemia, hepatic failure, thrombocytopenia, prostatic hyperplasia, chronic renal failure, lactation, psoriasis and pregnancy.

People with myocarditis, and other diseases of the myocardium in the admission of “Quinidine” requires regular medical monitoring. Before treatment the patient will need to make a correction of the symptoms of hypokalemia and failure of the heart.

In the process of therapy is required continuously monitor ECG, analysis data of peripheral blood and hemodynamic parameters.

Similar means, price

Analogues, the drug is very much. Experts attribute to him the following: “Kinidin Durules”, “Bracelet”, “Procainamide”, “Etatsizin”, “Waste”, “Amiokordin”, “Propanorm”, “Evidence”, “Verapamil”, “Propranolol”, “Rytmonorm”.

As for prices of these medicines as “It” and “the Quinidine Durules”, the inhabitants of ourof the country they are unknown due to the fact that these medicines are no longer sold in Russia. However, they can be purchased in Ukraine. The cost of drugs in this country is about 540 and 670-679 hryvnia, respectively, which is equal to 1380 and 1760-1780 rubles.

Reviews

What they say about the medication doctors and other professionals? According to them, this tool manifests itself as a very effective antiarrhythmic drug, which is well and quickly cures diseases such as ventricular and supraventricular tachycardia. However, it should be noted that to find the tablets “It” in Russian pharmacies is not possible. This is due to the fact that this drug has been excluded from free circulation and no longer used in hospitals. Doctors explain this situation by the fact that in the pharmaceutical market there are more safe and effective as well as inexpensive analogues, which are widely used for the same indications. The specialists claim that quinidine sulfate continues to be used as a constituent of multi-component substances in many antiarrhythmic drugs.