"Indapamide" - usage instructions

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2018-04-03 22:50:15

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Indapamide” – a drug belonging to the group tiazidopodobnye diuretics, and has hypotensive action. The cure "Indapamide" is indicated for use in the presence of hypertension.

Formdata drug "Indapamide"

 the manual notes that the pharmacological properties of medication related thiazide diuretica. The effects of the drug capable of selectively blocking “slow” calcium channels, contributes to the elasticity of arterial walls, thereby lowering total peripheral vascular resistance.

"Indapamide" does not change carbohydrate metabolism, and acceptable to patients with diabetes, and does not affect the concentration of lipids in plasma. Pills "Indapamide" contribute to the reduction of hypertrophy in the left ventricle of the heart, reduce the sensitivity of vascular wall to the noradrenaline and angiotensin II, stimulates the synthesis of prostaglandin E2, reduces the production of oxygen radicals. Usually by 5-7th day of treatment with the drug is the hypotensive effect retained in single dose for days.

The Pharmacokinetics of the drug "Indapamide"

The manual reports that the drug has a high bioavailability (93%) and the absorbability in the digestive tract. The speed of absorption is affected by food intake. The highest concentration of the drug in the blood within an hour or two after administration of the drug in an amount of 2.5 mg. the Drug is metabolized by the liver. 60%-80% of the substance is excreted via the kidneys in the form of metabolites, about 20% - through the intestines. The drug is not koumouliruet ability.

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Indications for use "Indapamide"

Manual prescribes the use of a drug for lowering blood pressure. The drug is also recommended for those with chronically leaky heart failure.

Contraindications

"Indapamide" is contraindicated in:

- hypersensitivity to it and other derivative sulfonamide group

- anuria

- hypokalemia

- severe hepatic or renal insufficiency,

- period of lactation,

acute pathology of cerebral circulation

-  pregnancy

the age of 18 (due to obscurity)

- concomitant use of drugs that increase the QT period.

Caution is prescribed this drug in the presence of gout and diabetes mellitus in decompensation stage.

Method of application and dosage of the medication  "Indapamide"

The manual recommends to take the pill inside, without chewing. 2.5 mg (daily dose) is best consumed in the morning or afternoon. In the case where a 1-2 month course of treatment with medication does not produce the desired therapeutic effect, it is not recommended to increase the dose in connection with an increased risk of side effects. In this case, a scheme of medical therapy of hypertension you need to add another antihypertensive agent that does not is a diuretic. In the treatment with two antihypertensive drugs drug dose "Indapamide" remains the same.

Overdosing

Overdose Symptoms are weakness, dysfunction of gastrointestinal tract, nausea, vomiting, fluid and electrolyte disorders. In some cases, may appear to overdose by respiratory depression and excessive lowering of blood pressure. In patients with cirrhosis of the liver can occur in hepatic coma.

In case of overdose it is necessary to carry out the correction to normalize fluid and electrolyte balance: gastric lavage and symptomatic therapy.

Interactions

Enhances the effect of other drugs from high blood pressure. Not recommended combined with medications containing lithium, vincamine has, kaliwavodaschimi diuretics.

Side effects of medication "Indapamide"

The Same as in cases of overdose. Possible cardiac arrhythmias due to potassium loss. Also side effects may occur weakness, a sharp decrease in pressure when you try to stand, nausea, abdominal pain, diarrhea, convulsions, allergic reactions. In rare cases, may exacerbate gout, cramps.


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Alin Trodden - author of the article, editor
"Hi, I'm Alin Trodden. I write texts, read books, and look for impressions. And I'm not bad at telling you about it. I am always happy to participate in interesting projects."

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