Antacids. Description

Antacids are a group of drugs that lower the acidity of the stomach contents. This effect is achieved by the adsorption or neutralization of hydrochloric acid in the gastric juice. It should be noted that antacids for the most part have adsorbing and neutralizing effect.

Mostly neutralizing activity characteristic of the compounds of some alkali metals. These include, in particular, include calcium carbonate precipitated, sodium bicarbonate, magnesium carbonate basic, magnesium oxide. Adsorbing activity possess ion-exchange resin and some aluminum compounds. Aluminium oxide, phosphate, hydroxide, particularly in the colloidal form, and also have enveloping effect, while increasing protection of the stomach lining, reducing the secretory activity of the pancreas.

Antacids, increasing the pH of the stomach contents up to 4.5, reduced peptic activity of gastric juice. Medicines with the aluminum content contribute to the inhibition of the activity of pepsin, reducing, thus, the value of the peptic factor in the formation of ulcers and maintaining inflammatory processes in the mucosa of the gastrointestinal tract. Colloidal antacids of aluminium (in particular in the form of a gel ‘aluminium phosphate gel”, “Almagell”) is formed on the mucosa in some way a protective layer. This layer adsorbs different damaging the mucous substances contained in the intestinal or digestive cavity, including toxins of the microbial body, the bile acids.

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Antacids. Classification

The Medicines differ depending on the ability to neutralize hydrochloric acid. So, for example, grams of sodium bicarbonate to neutralize approximately one hundred twenty milliliters of acid, gram of magnesium trisilicate – 155 ml, grams of precipitated calcium carbonate – 200 ml and so on. Among the means of the lowest activity of sodium bicarbonate, higher – magnesium oxide.

Antacids may act for several hours. Duration of activity can be increased holinoblokirutmi medicines, H-2 histamine antagonists and other drugs that reduce the secretory function of the stomach.

Among the quite common means of this group should be allocated to such medications, like “Maalox”, “Alamag”, “aluminium phosphate gel”.

The Latest medicine is a colloidal gel. The medication is taken orally. Prescribed for dyspepsia, gastritis – before eating, ulcers – after a meal in an hour or two, and you are experiencing pain – immediately. When reflux esophagitis – before going to sleep after eating, and dysfunction in the colon – at night and in the morning on an empty stomach.

The Drug “Maalox” is produced in the form of chewable tablets, powder and suspension. The product contains magnesium hydroxide and algeldrat. Usually recommend one to two tablets or a tablespoon of slurry per day.

Means ‘Alamag” is produced in the form of a suspension. The recommended single dose for adults-one teaspoon (tea).