The drug "Pentas": instructions for use, analogs, reviews and

Dose of prescribed medication “the Pentas”? Instruction manual, reviews and the drug is considered next. Also the article presents information on the release of this medication and its properties.

Structure, forms of medicine

There are several forms of issue under consideration the medication. Imagine them right now.

The Drug “the Pentas” pills (500 mg, 100 mg) prolonged action. They are white with a grayish tinge, and with numerous light brown specks, round, valium, chamfered labels on both sides.

An Active element of this medicine is mesalazine. Also, the composition includes inactive ingredients in the form of povidone, derivatives cellulose, magnesium stearate, talc and microcrystalline cellulose.

The drug “the Pentas" (tablet), photo in the paper, it comes in blister packs, which are packs of cardboard.

It should Also be noted that the medication can be purchased in the form of suppositories, granules of prolonged action and rectal suspension.

Pharmacy medication

What is the medication “the Pentas”? Instruction manual says that this remedy has anti-inflammatory and used to treat ulcerative colitis and Crohn's disease.

Anti-Inflammatory properties of this drug are shown only for local use. This action is due to the synthesis of leukotrienes and prostaglandins, and inhibition of the activity of lipoxygenase (neutrophilic). In addition, this tool is able to slow down the secretion of immunoglobulins by lymphocytes and inhibit the degranulation, migration and phagocytosis of neutrophils.

Intestinal

The Drug “the Pentas" (tablets), the composition of which has been presented above, shows a pronounced antibacterial activity against some cocci and Escherichia coli. It also has antioxidant effects due to the ability of the active substance to contact with free radicals (oxygen) and destroy them.

Correct use of this tool greatly reduces the risk of relapse in Crohn's disease, including in people with ileitis (long disease duration).

The Principle of medical facilities

How does the drug "Pentas”? Instruction manual claims that the therapeutic effect of this drug appears immediately after local contact with mesalazine intestinal mucosa.

After taking oral treatment tablet immediately disintegrates into microspheres, which act as independent forms and delayed release the active substance – mesalazine. This ensures the effectiveness of medication over a 12-perstny to the rectum at any pH.

The Pharmacokinetics of funds

How is the absorption of the drug “the Pentas”? Instruction manual reports that the microspheres disintegrated tablets reach 12 duodenal ulcer during the first 60 minutes.

Approximately 30-50 % of the accepted dosage of the medication is absorbed in the small intestine. Connection with plasma proteins mesalazine is 43 %, and acid N-acetyl-five-aminosalicylic – 73-85 %.

Mesalazine and its derivatives do not penetrate the GEB. The cumulative properties of the drug manifest themselves only at high dosages (approximately 1500mg a day).

Acetylation of mesalazine undergoes in the intestinal mucosa and liver. This substance is excreted with urine, breast milk and feces.

Indications for use medication

In some cases, can be shown the drug “the Pentas" (tablets)? Specialists say that the drug performs well in:

• Ulcerative colitis;
• Crohn's disease.

Prohibitions to the use of the medicinal product

Under what conditions you cannot use a tool such as “the Pentas”? User manual (tablet, and other forms of the drug have the same contraindications) speaks the following restrictions:

• Hemorrhagic diathesis;
• Diseases of the blood;
• Lactation;
• Ulcers of the digestive tract;
• The last 2-5 weeks of pregnancy;
• Lack of glucose-6-phosphate dehydrogenase;
• The age of two years;
• Renal failure severe;
• Hypersensitivity to the substances of the product;
• Liverfailure hard.

With extreme care considering medication use in the first trimester of pregnancy, and in hepatic and renal nedostatochnosti.

Medication “the Pentas": usage instructions

The Choice of the dosage form of this drug depends on the localization of the main pathological process and the extent of intestinal injury.

Suppositories “the Pentas” and the suspension is administered in the distal forms of the disease (proctosigmoiditis). The candles use three times a day at 500 mg.

As is prescribed oral medication "Pentas" (tablets)? Instruction manual States that this type of medication is recommended only in the common forms of diseases. Prevention of relapse in Crohn's disease the drug use four times per day (1 g mesalazine). With regard to prevention of relapses of ulcerative colitis, in this case, the drug is prescribed three times a day at 500 mg.

In exacerbation of the disease course of therapy should last 8-12 weeks. At the same time every day should take 400-800 mg of medications (three times a day).

In severe disease may increase the daily dose to 3-4 g.

Tablets “the Pentas” it is desirable to take immediately after a meal, not chewing and drinking plain water.

Effects side nature

In some cases the drug causes the following side effects:

• Stomatitis, tremor of the extremities, dry mouth, dizziness, nausea, depressed mood;
• Loss of appetite, feeling palpitations, heartburn, shortness of breath during physical activity, vomiting;
• Hematuria, diarrheal syndrome, tachycardia, hepatitis, chest pain;
• Increase of liver enzymes, fluctuations in blood pressure, pancreatitis, polyneuropathy;
• Crystalluria, tinnitus, proteinuria (protein secretion), migraine headaches;
• Oliguria, leukopenia, anuria (absence of urination), and thrombocytopenia, the formation of nephrotic syndrome;
• Hypoprothrombinemia, agranulocytosis, eosinophilia, anemia.

It should Also be noted that while taking this drug, the patient may experience: oligospermia, alopecia, photosensitivity, weakness in the limbs, volchanochnopodobny syndrome, decreased production of tear fluid, mumps.

Overdose medication

An Overdose of the considered tool appears increased drowsiness, nausea, gastralgia, vomiting and weakness throughout the body. To eliminate these symptoms requires timely gastric lavage and the appointment of purgative medicines and conducting posindromnoy therapy.

Drug Interactions

The Drug “the Pentas” can slow the rate of absorption of cyanocobalamin. Also mesalazine increases the effectiveness of uricosuric drugs (including blockers kanalzeva secreta).

Not to mention the fact that this drug increases the ulzerogennosti glucocorticoids reduces the effect of rifampicin, enhance the toxicity of methotrexate, and has a hypoglycemic effect on sulfonylureas, spironolactone, sulfonamides and furosemide.

Special information

When skipping one dose of mesalazine, it is recommended to take together with the next or in the near future. If it was missing a few doses, you should immediately contact a doctor. In this case do not attempt to stop treatment.

Sometimes the background of the application of this means the patients have staining of urine and contact lenses in orange color with yellowish tint.

In the process of treatment with mesalazine requires constant medical supervision over the work of the renal system of the patient. Also should regularly conduct urine analysis of the patient and his blood (throughout the course of therapy and after its completion).

The Probability of occurrence of adverse reactions in patients receiving this medication increases in those who are “slow acetylators”.

With the development of acute syndrome of intolerance to the current drug ingredient "Pentas” immediately canceled.

Similar drugs, and consumer reviews

Are you Aware of the fact than you can replace considered a medicine? You must inform the attending doctor. Typically, the analogs of this tool include the following drugs: “Mesacol”, “Salosina”, “salofalk worth us”, “Musavat”, “Mesalazine", "Asacol".

What you say about this tool, consumers? According to their reviews, the medication is a highly effective drug that can be purchased at any pharmacy. Patients say that mesalazine is very successful not only in therapy but also in prevention of Crohn's disease and ulcerative colitis.