"Nimesulide": reviews, use, analogs

Nonsteroidal anti-inflammatory drugs are a special class of drugs having three significant effects: anti-inflammatory, antipyretic and analgesic. Due to these pharmacodynamic features of this group of drugs is widely used in the practice of medicine. Let's look at features of using the drug "Nimesulide" the opinions of patients about the medication and possible adverse effects, and features of batching.

Pharmacodynamic features

“Nimesulide" is representative of the group of non-steroidal anti-inflammatory drugs. In the group the drug belongs to selective inhibitors of the enzyme cyclooxygenase-2, which effectively suppresses the production of prostaglandins in inflammation.

Another distinctive feature of the mechanism of action of the drug "Nimesulide" is its ability to inhibit the release of enzyme called myeloperoxidase that significantly inhibits the production of free radicals, without affecting the processes of chemo - and thigmotaxis and phagocytosis. In addition, "Nimesulide" contributes to the inhibition of the formation of tumor necrosis factor and other mediators involved in inflammatory reactions.

Pharmacokinetic features

Major route of introduction of this drug is oral, due to the high bioavailability of the drug, the rate of achievement of maximum concentration in the blood plasma of patients. So, the highest concentration is reached after 120-180 min after ingestion, and the degree of binding of drug with blood plasma proteins is approaching 98% of the originally introduced quantity of the drug "Nimesulide" (testimonials from patients and doctors confirm it).

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The Main body, in which the metabolism of the drug is liver. In the process of biotransformation into active metabolite called gidroxinimesoulid. The main route of elimination of a drug is its excretion in the urine (so it appears about 65% of the drug), about 35% of the drug is excreted with fecal masses.

Almost all patients before receiving interested in any additional information about the drug "Nimesulide". Instructions for use, analogues, indications and contraindications, side effects – frequently asked questions.

Indications

The Indications for the drug “Nimesulide" not so much. Among them occurring acute pain, primary osteoarthritis with pain syndrome and primary dysmenorrhea occurs. In pediatric practice effectively in the use of the drug. This is evidenced by the left of the reception facilities "Nimesulide" reviews. For children under 12 years of age to buy it is not recommended - this should be remembered.

Contraindications for the drug

Like all non-steroidal anti-inflammatory drugs, "Nimesulide" is contraindicated in the presence of the ulcer of the stomach or duodenum (duodenum 12) in the acute stage, reducing the detoxification functions of the liver, the simultaneous appointment of drugs with hepatotoxic drugs. The drug is contraindicated in persons with a significant decrease in renal excretory function (creatinine clearance less than 30 ml/min), haematological disorders and problems of blood coagulation system in patients with dysfunction of the cardiovascular system.

“Nimesulide" is contraindicated in patients with surgical pathology, pregnant or breast-feeding, and children under 12 years because of the high probability of side reactions. It is not necessary to assign the "Nimesulide" for the treatment of influenza and influenza-like conditions of hyperthermia.

Side effects

This tool is not only has high anti-inflammatory activity, but also a high incidence of adverse reactions. They arise, usually during the first weeks of drug therapy "Nimesulide". The feedback regarding the side effects leave much to be desired.

From the skin side and the skin side effects associated with allergic symptoms and reactions to the drug, which is manifested in emergence of skin itching and rashes, dermatitis, redness, hives. Much less have side effects such as toxic epidermal necrolysis, the Stevens-Johnson syndrome.

The part of the gastrointestinal tract rarely may cause bleeding, perforation of ulcers. Much more likely to have painful sensations in the epigastric region, nausea, vomiting, diarrhea or constipation.

From the Central nervous system, you may experience apathy, excessive sleepiness, constant headaches and unreasonable vertigo, vestibular disorders.

The hematopoietic system and the cardiovascular system may develop eosinophilia, thrombocytopenia andpancytopenia, anemia, tachycardia, high blood pressure, hyperkalemia.

Application "Nimesulide" and reviews

Using "Nimesulide" took its place in the clinical practice of rheumatic diseases of locomotor apparatus. Despite significant limitations in the indications for the drug “Nimesulide" of the reviews about it are positive due to the high effectiveness in the treatment of rheumatic diseases. This is due to the specificity of the effects on cyclooxygenase-2 and the high degree of selectivity to this enzyme.

Special instructions

What you need to be wary when receiving such drug as "Nimesulide"? Instruction manual, reviews patients informed about some warnings. An important moment in the drug "Nimesulide" is the use of minimum therapeutic doses of the drug. In case of lack of efficacy in a minimum dosage of the medication should be stopped.

In the case of hepatotoxic action of the drug (which is monitored by biochemical parameters of the blood) medication also should be stopped immediately. This group (which develops the cellular damage of the liver) further prohibited the appointment of "Nimesulide". It should be noted that even in the absence of side effects in the liver, the drug should not be combined with hepatotoxic medications, other nonsteroidal anti-inflammatory agents, analgesics. We should also refrain from drinking alcohol.

“Nimesulide" follows with a high degree of caution appoint patients with hepatic or renal insufficiency to avoid the risk of progression of the latter.

Particular attention should be paid to the appointment of the drug patients with flu-like symptoms. This is due to the fact that "Nimesulide" has antipyretic effect and can mask the symptoms of a bacterial infection.

Drug interactions

Due to the high ability of the drug to cause intestinal bleeding "Nimesulide" should not be combined with anticoagulants such as "Warfarin" since there is a high risk of side effects.

Well-Known ability of the drug to disrupt the function of cytochrome P450. Due to the oppression of functional activity of this enzyme, the dose of drugs metabolized by this cytochrome should be revised downward.

“Nimesulide": analogs reviews

The Major analogues (for active substance) are ‘Nimid”, “Nimesil”, “Nimesulide», «Toro-sanovel”. The drug is available in tablet form, in sachet of 100 mg or in the form of gel for 10 mg (1 g gel). Therapeutic activity of analogues of the drug is good, so reviews about them patients leave also positive. Patients, leaving about "Nimesulide" reviews, tablets become smaller than the drug in the form of sachets.

Conclusion

“Nimesulide" is a powerful anti-inflammatory agent for the treatment of inflammatory diseases, mostly musculoskeletal. Due to the high risk of side effects, be sure to consult with your doctor about taking the drug "Nimesulide". The doctors prescribing this drug, and patients receiving it, positive, as it contributes to the rapid reduction of the disease symptoms.