Benzylpenicillin sodium salt: instructions for use. Application rules

In this article we will talk about this drug, as “Penicillin g sodium”. Instructions for use, indications, dosage and recommendations for use will be covered in the article. In addition, we consider the pharmacological properties of the drug, possible side effects and interaction of the drug with other drugs.

General data

The Drug is an antimicrobial agent and an antibiotic belonging to the group of penicillins. She benzylpenicillin sodium salt, instructions for use which will be described below, is produced by various fungi.

Drugs in this group are used for intramuscular injection, effects on various tissues and organs in which the blood delivers a small amount of penicillin. To the drug began to have an effect on the brain and spinal cord, and meninges, subarachnoid it is administered.

Penicillin g sodium, instructions for use: a pharmacological action of

The Drug is effective against gram-positive bacteria, which include:

• Staphylococcus;
• Streptococci;
• Pneumococci;
• The causative agents of diphtheria;
• Bacillus anthracis;
• Aerobic (surviving in the absence of oxygen) spore-forming bacilli.

In addition, the drug is active against gram-negative cocci (meningococcus, gonococcus), spirochetes, actinomycetes and other microorganisms. Ineffective benzylpenicillin sodium salt against viruses, rickettsiae, fungi, protozoa.

Drug-Resistant strains of staphylococci are able to produce the enzyme penicillinase, the penicillin disintegrating. The drug exhibits a low activity in the treatment of Pseudomonas aeruginosa, intestinal bacteria and other microorganisms that in different amounts to allocate penicillinase.

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Pharmacokinetics

Intramuscular administration the drug rapidly enters the blood where it is delivered to other body fluids and tissues. With regard to cerebrospinal fluid, it penetrates a small amount of penicillin. The highest concentration of a substance in the blood after intramuscular introduction it is noted in 30-50 min when the drug was administered subcutaneously, the rate of absorption will decrease and the greatest amount of a substance in the blood will occur in an hour.

Three hours after the injection (subcutaneous or intramuscular) in the blood will remain only traces of penicillin. Therefore, in order to maintain a high concentration of the drug in the body for a long time, it is necessary to inject through every four hours.

When the drug is administered intravenously, its concentration decreases rapidly. But when taken orally benzylpenicillin is destroyed by penicillinase (an enzyme) and gastric juice.

The body of the drug is excreted in the urine.

Readings

Needs to be examined carefully before prescribing this drug as benzylpenicillin sodium salt, instructions for use, doses and indications for use. Let's start with the latter. So, the drug is prescribed:

• In diseases of the lungs and respiratory tract;
• Severe septic diseases;
• Septic endocarditis;
• Sepsis;
• Infections and infected wounds of soft tissues, skin and mucous membranes.
• Burns;
• Inflammation of the spinal cord and brain, mozgovykh shells;
• Purulent pleurisy;
• Peritonitis;
• Cystitis
• Pyemia and septicemia;
• Osteomyelitis;
• Diphtheria.
• Scarlet fever;
• Gonorrhea;
• Erysipelas;
• Ophthalmia in newborns;
• Anthrax;
• Syphilis;
• Actinomycosis;
• Various gynecological inflammation;
• Inflammatory diseases of the throat, ear and nose.

Rules of use and dosage

Depending on the diagnosis can be assigned to different treatment using the drug penicillin sodium salt. Instructions for use, method of administration and possible dose will be discussed in this section.

Treatment drug can last, depending on the disease, from 4 weeks to 2 months or even more. The drug can be administered in the following ways:

• Intramuscularly in the upper outer gluteal quadrant. The drug is diluted prior to introduction into distilled water, novocaine solution or sodium chloride.
• Intravenous – only with such a serious illness, such as meningitis, bacterial endocarditis, sepsis, etc. the Drug is administered every 4 hours or a continuous drip method – 30 drops per minute for 6-12 hours.
• Also can be administered endolyumbalno penicillin g sodium. Instructions for use (application method) this method involves inflammation of the spinal cord and brain, including the meninges. The drug is administered very slowly-1-2 minutes.
• There Are cases when benzylpenicillin is used for injecting the inflammatory foci. For example, if actinomycosis, leishmaniasis of the skin, chronic pyoderma and other infectious skin diseases.
• With inhalation – for the treatment and prevention of diseases of the lungs and respiratory tract. For this mix penicillin with sodium chloride solution or distilled water. Are inhalation of not more than 2 times a day. Long one procedure – from 10 to 30 minutes.
• The Drug is also injected in the pleural or abdominal cavity with purulent pleurisy or peritonitis.
• In the form of washes, ointments, wet dressings, lotions and powders – for burns, wounds of soft tissues, osteomyelitis, etc.
• Also used the solution of the drug in the treatment of ENT diseases and in ophthalmology.

Benzylpenicillin may be used in therapy with other antibiotics and sulfa drugs. The tool will enhance the therapeutic effect of used drugs.

Side effects

Can also have negative effects benzylpenicillin sodium salt. Instruction manual notes that most often they appear with intravenous administration of the drug.

Mostly the side effects associated with allergic reactions to the drug. Among the unfavorable symptoms are:

• Candidiasis;
• Hives;
• Fever;
• Headache,
• Fever;
• Pain in the joints;
• Angioedema;
• Eosinophilia;
• Different types of dermatitis;
• Fever;
• Lymphadenopathy;
• Anaphylaxis – in very rare cases.

Contraindications

Not all patients may be suitable for treatment using the drug penicillin sodium salt. Application instructions and rules of administration provide for a number of contraindications. Among them:

• Allergic diseases such as urticaria, hay fever, bronchial asthma, etc.;
• Increased sensitivity to a derivative of penicillin;
• An unusual reaction to the drug;
• Resistance of the causative agent to a standard dose of penicillin.

The introduction of the drug is able endolumenal prohibited in epilepsy.

Pregnancy and lactation

Assigned during pregnancy only if the benefits of treatment for women will exceed the potential risk to her unborn child. Otherwise, the drug is not appointed. The balance of risk and efficiency shall be determined by the attending physician.

If necessary, taking the drug during lactation period breast feeding should stop.

Properties

Drug benzylpenicillin sodium salt is a white crystalline powder with a bitter taste, which readily dissolves in liquid.

The Drug is easily destroyed by acids, alkalis, oxidizers, enzyme penicillinase, as well as when heated. To prepare the medicinal substance must be immediately before the introduction.

Precautions

The Drug is administered only in stationary conditions by the doctor and under his supervision. When therapy need to remember that an insufficient dose of penicillin or early completion of treatment can lead to the formation of resistant strains of microorganisms. If you encounter resistance to the drug being treated with other antibiotics.

When the tendency to allergic reactions is administered along with antihistamines, the drug benzylpenicillin sodium salt. Application instruction (drug action it prescribes in great detail) informs that, in appearance...