"Vilprafen 1000": user manual, analogs, reviews

What is the drug “Vilprafen 1000”? The answer to this difficult medical issue you will find in the materials of the article. Also from it you will learn about how to take this medication, for which it is intended, whether the adverse reactions and contraindications, than it can be replaced, and so on.

Structure, packing and release form medical facility

The Drug “Vilprafen 1000” can be purchased at the pharmacy in the form of dispersible tablets of white color (can be with a yellowish tinge). They have an elongated shape with a mark and the inscription “pass” on one side, with the numeral "1000” on the other. It should also be noted that this tool has a sweet taste and aroma of strawberry.

Active substance of the drug “Vilprafen 1000” is josamycin. As for the helpers, these include aspartame, hyprolose, silica colloidal anhydrous, cellulose microcrystalline, sodium docusate, strawberry flavor and magnesium stearate.

In the sale of the drug comes in blister of 5 tablets, placed in a cardboard box.

Pharmacological action of the medicinal product

What is the medication “Vilprafen 1000”? Instructions for use of this medication indicates that the tool is an antibiotic belonging to the macrolides group.

The Mechanism of action of the considered drug is associated with impaired protein synthesis in the microbial cells. Such an effect is due to reversible binding of the active substance with 50S-subunit of ribosomes.

Recommended

A tablet from worms – the relevance of the application for the person

How relevant today, drugs against worms in humans? What kind of creatures these worms, what are modern methods of treatment? We will try to answer these questions, since ignorance in this area is undesirable. Imagine a mummy, which is misleading in k...

What to do if you cracked skin on hands?

Each of us at least once in a lifetime encounter with a small, but very, when the crack the skin on the hands. At this time there are wounds of different sizes, which hurt and cause inconvenience, especially when in contact with water or detergents. ...

Spray Macho man - the key to a proper relationship between the two spouses

Male impotence is a pathological condition associated with abnormal physiological capacity of the penis to reginout and bring sexual partner pleasure in bed.sex impotenceimpotence may not men to pass unnoticed – it usually spoils his nervous sy...

Therapeutic amounts of this tool is capable of exerting a bacteriostatic effect, slowing down the reproduction and growth of bacteria. If you create in the inflammation high concentrations, bactericidal effect is possible.

The Drug “Vilprafen 1000” is particularly active against gram-positive and gram-negative microorganisms. While it has no effect on enterobacteria. In this regard, the drug cannot have a negative impact on the state of the microflora of the gastrointestinal tract.

In some cases, the medication remains active in resistance to erythromycin and other macrolides.

The Pharmacokinetics of medicinal products

How long the drug is absorbed “Vilprafen 1000”? Manual of this tool says that after intake the active element of the medicine is rapidly absorbed from the gastrointestinal tract. The meal does not affect its bioavailability.

The Highest concentration of drug achieved in about an hour after ingestion. At a dose of 1 g, the maximum concentration is about 2-3 mg/ml.

Active substance of the medicine is quite well distributed in the tissues and internal organs (except the brain). The drug creates concentrations that exceed plasma and stored at therapeutic levels for a long time.

High concentrations of josamycin observed in the tonsils, lungs, saliva, lacrimal fluid and sweat. The drug easily passes through the placental barrier and secretiruetsa in breast milk.

Josamycin (active substance of the drug) metabolized in the liver. With the formation of active metabolites.

The drug is Excreted mainly in the bile. But excretion along with the urine does not exceed 10 %.

Indications for use of medical tools

In some cases, you should use the drug “Vilprafen 1000”? Reviews about this medicine will be described later. Now I want to tell you that this medication is prescribed only in infectious and inflammatory diseases which was caused by sensitive micro-organisms means:

• Diphtheria (as an adjunct to therapy with diphtheria antitoxin);
• Infections of ENT organs and respiratory tract (laryngitis, pharyngitis, middle otitis, tonsillitis, sinusitis and paratonzillit);
• Infections of the lower respiratory tract (exacerbation of chronic bronchitis, acute bronchitis, community-acquired pneumonia);
• Pertussis;
• Scarlet fever (if there is hypersensitivity to penicillin);
• Infections of the oral cavity (pericoronitis, gingivitis, alveolitis, periodontitis, alveolar abscess);
• Fever;
• Infections of the soft tissues and skin (furuncle, folliculitis, acne, furunculosis, lymphangitis, abscess, cellulitis, lymphadenitis, panaritiums, wound, burn, and postoperative infections);
• Infections of the eye (in dacryocystitis and blepharitis);
• Face (if you have hypersensitivity to penicillin);
• Anthrax;
• Infections of the genitals and urinary tract (cervicitis, urethritis, prostatitis, epididymitis);
• Lymphogranuloma venereum;
• Diseases of the digestive system associated with Helicobacter pylori;
• Syphilis and gonorrhea (if there is hypersensitivity to penicillin).

Contraindications for use medication

In some cases, the drug use “Wilprafen Solutab 1000”? Specialists say that this drugthere are the following contraindications:

• Children with small body mass (less than 10 kg);
• Severe violations of the liver;
• Hypersensitivity to the active substance;
• Increased sensitivity to the antibiotic drugs belonging to the group of macrolides.

Drug “Vilprafen 1000": manual for use of the drug

The Dosage of this drug should be determined only by the attending physician and only in individual cases.

For adults and adolescents 14 years and older, the usual amount is 1-2 g. it is recommended to Take 2-3 hours. If necessary, the dose may be increased (for example, up to 3 g per day).

The Daily dose for children, whose body weight is not less than 10 kg, shall be appointed on the basis of calculation 40-50 mg per kg of weight. Receiving medication need to exercise 2-3 times a day.

Based on the foregoing, it is easy to calculate that the child body weight 10-20 kg should be given at 250-500 mg twice a day (a quarter or a half tablet, pre-dissolved in water).

The Child with a body weight 20-40 kg given at 500-1000 mg twice a day (or half a tablet dissolved in water).

Children weighing more than 40 kg-1000 mg (i.e. one tablet) twice a day.

How should take the drug “Vilprafen" (1000 mg)? Duration of treatment with this remedy is determined only by the doctor (it is usually 5-21 days, depending on the severity and nature of infection).

Schema therapy of H. pylori (stomach ulcer treatment)

Now you know how to take “Wilprafen Solutab 1000”. If you need therapy of H. pylori, the drug used in amount of 1 g twice a day for 1-2 weeks. The drug should be combined with other drugs in standard doses (‘Famotidine", "Omeprazole" "Omez", "Omez D" and so on.).

Dispersible medication can be taken internally in different ways. With the pills (washed down with water) or pre-dissolved in 20 ml of water. In the latter case, the reception should be thoroughly mixed the resulting suspension.

Side effects after using medication

Analogs “Vilprafen 1000” and considering the drug can cause several adverse reactions. Among the side effects most frequently observed are the following:

• Digestive tract stomach discomfort, abdominal discomfort, nausea, diarrhea, stomatitis, vomiting, constipation, pseudomembranous colitis and loss of appetite.
• Allergic: urticaria, anaphylactoid reaction, erythema multiforme exudative, angioedema, bullous dermatitis, Stevens-Johnson syndrome).
• Jelcevwodyashih way and the liver: jaundice, hepatic dysfunction.
• Senses: a dose-dependent transient hearing loss.
• Other: purple.

Interaction with other medical products

As bacteriostatic antibiotics can reduce antimicrobial action of bactericidal antibiotics, it is necessary to avoid their common use.

Josamycin is strictly forbidden to assign along with lincosamide. This is due to the fact that a mutual reduction of their efficiency.

Representatives of the macrolides significantly slow down the elimination xantinov. This can lead to the appearance of symptoms of intoxication.

When used together, josamycin and antihistamines that contain astemizole or terfenadine may increase the risk of arrhythmias, life-threatening.

There are reports of increased vasoconstriction as a result of joint use of antibiotics from the macrolides, and of ergot alkaloids.

Co-administration of cyclosporine and josamycin causes an increase the level of cyclosporine in the blood, and increases the risk of nephrotoxicity.

When used together digoxin and josamycin, may increase the level of first blood.

Special instructions for use of medicinal product "Vilprafen 1000"

In the case of severe and persistent diarrhoea, you must keep in mind the likelihood of developing life-threatening pseudomembranous colitis (in patients receiving josamycin).

In patients with renal insufficiency therapy is recommended based on the results of laboratory tests.

You Must consider the probability of cross-resistance to various antibiotic remedies, belongs to the group of macrolides (bacteria that are resistant to treatment with antibiotics, related in chemical structure, can be resistant to josamycin).

Cost and equivalent drugs

The drug Price considered not very high. So, for 10 tablets of the drug you will have to pay about 150 rubles. Agree, this is a fairly low cost, considering the effectiveness of the drug “Vilprafen 1000”. Counterparts cheaper, you are unlikely to find in pharmacies.

If you are considering contraindicated medication, then it can be replaced by one of the following drugs: “Midecamycin”, “Roxithromycin”, “Spiramycin”, “Clarithromycin”, “Azithromycin” or “Erythromycin”. These drugs same active substance.The so-called structural analogues of this medication.

Testimonials from patients and professionals about medical tool

Today, there are quite a large number of positive reviews about this medication. Patients ever taking this drug, noting its rapid therapeutic effect, which is noticeable after the first dosage. This is particularly true when an abnormality such as angina, otitis, sinusitis and cystitis.

Side effects after the medication is rare. The authors of some of the reviews talk about the disorder of the chair, and periodic nausea. By the way, these unpleasant effects disappear spontaneously in a few days.

It Should also be noted that a large number of patients pleased with the price of this drug.

The specialists mentioned the possibility of drug treatment “Vilprafen” during pregnancy.