"Leflox": instruction manual, reviews, analogs

“Leflox” included in the group of fluoroquinolones. The drug has antimicrobial effect. The main component of the drug-levofloxacin. Solution and tablets “Leflox” indications: skin infections, infectious processes in soft tissues, septicemia, community acquired pneumonia, bacterial prostatitis etiology, sinusitis, otitis and other diseases of infectious nature.

Structure and form of the drug “Belocca”

The Drug is manufactured in two dosage forms – tablets (packs of 5 and 10 pieces), solution for intravenous injection (vial of 100 ml). The solution contains 5 mg/ml of active ingredient. Tablets can be composed of 250 or 500 mg of the main component.

Part of the tablets includes a number of excipients: Polysorbate 80, magnesium stearate, crospovidone, hypromellose, microcrystalline (Avicel PH 101, 102).

Antibiotic “Leflox” in the form of tablets coated to form which uses iron oxide (yellow, red), macrogol, titanium dioxide. The solution, as auxiliary components it contains sodium hydroxide, water for injections, hydrochloric acid and anhydrous dextrose.

Pharmacological action of the drug “Leflox”

Active component depressing effect on DNA synthesis of bacteria. Occur morphological changes involving the cytoplasm, membrane, cell wall of microorganisms and causing their death. These processes provide a bactericidal and antimicrobial effects. To the drug sensitive some anaerobes and aerobes (gram-positive, gram-negative), other microorganisms.

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The oral use of drugs ‘Leflox” the composition of this tool is rapidly absorbed in the digestive tract almost completely. When the dosage of the active substance of 500 mg the bioavailability is almost 100 per cent, tying with plasma – an average of 35 percent. The drug penetrates well into certain tissues and organs. A small part of oxidized deacetylated in the liver. Mainly in the excretion of the drug from the body involves the kidneys.

Indications for use of the drug “Leflox”

“Leflox" of the analogues used in the skin lesions, prostatitis, disease, which affects the respiratory tract, organs that comprise the urinary system. The medication is used as additional means in the treatment of tuberculosis, the form of which is determined as stable.

Drugs to treat infectious-inflammatory diseases resulting from negative effects of microorganisms with different sensitivity to levofloxacin. “Leflox” instruction manual allows you to assign in cases where detected:

• Prostatitis bacterial etiology;
• Sinusitis in acute form;
• Intra-abdominal infection;
• Keen bronchitis chronic forms;
• Infectious processes in the urinary tract with complications or without them;
• Infection, affecting the skin and soft tissue.
• Community-acquired pneumonia;
• The disease, which affects the ENT organs;
• Septicemia;
• Bacteremia;
• Tuberculosis that is resistant to the effects of drugs (designation “Belocca” carried out using combination therapy).

Contraindications for the drug “Leflox”

For a drug there are several contraindications. “Leflox" instructions for use does not allow the use in epilepsy, convulsive syndrome, pregnancy and lactation. The drug is not prescribed to patients whose age is less than 18 years of age. Contraindications include lesions of the tendons, became held hinolonami therapy and the body's hypersensitivity to the components of the tool. Therefore, before applying you should carefully study the drug and to consult with a specialist.

During the therapy requires special attention to the patient during the disorders in the kidneys, the deficit glukozo-6-fosfatdegidrogenaza. During treatment, older patients also need medical supervision.

Use of drugs ‘Leflox”

“Leflox" of the analogues, it is recommended to use between meals or before them (30 minutes before a meal). Tablets can be taken only in whole with sufficient amount of warm water.

Mostly at the initial stage of treatment every day inside the drug is taken in compliance of 1-2 hours. The dosage depends on the disease, severity of disease and sensitivity to drug of the causative agent of the disease.

Usually, when creatinine clearance greater than 50 ml/min, apply the following treatment scheme:

• Complicated chronic bronchitis – dose per day, 250-500 mg, duration of the course: from one week to ten days;
• Acute sinusitis – the cure "Leflox" (500 mg) is taken every day for ten days or two weeks;
• Community-acquired pneumonia-the use of 1000 mg of the drug per day in 2 doses for 1-2 weeks;
• Complicated infection that affects the urinary tract – the daily dose corresponds to 250 mg of the drug, the duration of the course is a little more than a weekif necessary, the treatment is extended;
• Pathology, which affects the urinary tract and there are no complications – roughly 4 days is taken for 250 mg drugs;
• Prostatitis caused by bacteria – requires prolonged treatment, sometimes within 28 days of taking 500 mg “Belocca” every day;
• Sinusitis-treatment produce tablets in a daily dose of 500 mg;
• Intra-abdominal infection – dose for daily use is 500 mg, duration of treatment in the complex treatment – 1-2 weeks;
• Diseases in which affects the skin and soft tissues, – need to be in therapy with a double intake of 250 mg or 500 mg means daily not more than two weeks;
• Tuberculosis resistant to the action of other drugs – for a comprehensive treatment you need each day, take 500 mg of funds (may receive up to 2 times) for three months.

Patients with kidney disease under certain values of KK (ml/min) «Leflox” instruction manual allows you to take the following:

• KK 50-20 – first take 250 mg, later – 125-250 mg (can be split into several doses);
• KK 10-19 – first a day take 500 mg, further treatment – 125 mg 12-48 hours;
• KK 10 below – are doing everything the same as in the previous case, but the drug is not used once in 12-48 hours, once every 1-2 days.

Made from a solution “Leflox” the IV is at least an hour. Further treatment depends on the patient's condition. A transition to the pill to the dosage, which was put dropper. In cases where the human body was exposed to peritoneal dialysis and hemodialysis, the introduction of additional doses of the drug are required.

Older patients who have liver problems, is performed in 48-72 hours or longer, until symptoms resolve, the complete destruction of pathogens.

If it was skipped the next dose, the next dose is administered either accept as soon as possible, then comply with the established treatment plan.

Side effects of the drug “Leflox”

“Levofloxacin” (“Leflox”) may provoke the development of side effects. Among the possible adverse reactions of the body – the emergence of dysbiosis, toxic hepatitis, enterocolitis, dyspepsia. Can be muscle pain, abdominal pain, headache, diarrhea, convulsions, tremors, temperature. If adverse reactions to the drug in the liver enzymes may be increased activity. When encountering such side effect as pseudomembranous colitis, further treatment becomes impossible.

The drug is sometimes accompanied by discoordination when making movements, the presence of emotional lability, depression, and sleep problems. In some cases seen disturbances of consciousness, of smell and taste. To the list of adverse reactions include arthralgia, thrombocytopenia. May develop agranulocytosis, paresthesia. The patient may present with leukopenia, eosinophilia.

As for other side effects during treatment means “Leflox" instructions for use include asthenic syndrome, hypoglycemia, fever, porphyria in an aggravated form, increased appetite, tachycardia, arrhythmia and a significant decrease in blood pressure (there is a likelihood of collapse).

Sometimes there are allergic reactions, a burning and itching of the skin, tremors in the limbs. Possible secondary infection. It is not excluded the appearance of photosensitivity, neuropathy. Detection of any side effects – a reason for seeking medical attention.

Overdose “Belocca”

Since the antidote is missing, overdose requires the implementation of symptomatic therapy. Among the most effective methods to eliminate this condition – peritoneal dialysis, hemodialysis.

Special instructions

Patients who left treatment means “Leflox" of the reviews, misleading about the careful use of medication in certain cases. Some patients required medical supervision.

With the disappearance of the high temperature of the body therapy should continue for 2-3 days. Treatment of severe pneumonia requires the use of several drugs, otherwise the desired result may be missing.

During therapy should avoid exposure to sunlight, artificial ultraviolet light because of the risk of photosensitivity.

There are other nuances that require attention. Of any changes in health should inform the doctor.

A combination of the drug “Leflox” with other drugs

Interacting with certain medications “Leflox” increases their effect or weakens. The same thing can happen with the action of the drug itself. If necessary, the treatment of other medications during therapy ‘Belocca” to consider that they may be incompatible. Any changes in medication should be discussed with your doctor.

The Cost of “Belocca”

Depending on the dosage form of the drug “Leflox” the price is about 760-940.tablets at a dosage of 500 mg (No. 10). About 345-450 RUB is a solution for intravenous injection (100 ml).

Reviews about the drug “Leflox”

In General, patients appreciate the drug. In their opinion, “Leflox” is efficient and allows to cure many diseases of infectious etiology.

The Drug is often prescribed to patients with the need to deal with several causative agents of pathological conditions.

Left after therapy means the ‘Leflox» reviews reflect the presence of rare cases of the appearance of negative reactions. Side effects often are mild and disappear when therapy is completed.

Analogues of the drug “Leflox”

Medication, which is similar to what has on the body ‘Leflox" exist in large numbers. It is possible to allocate such drugs as “Malevo”, “Liebeg”, “Found”. Aware of the possibility of using as substitutes for “Levontina”, “Action”, “Glevo”, “Ivanina”. These funds are the most common and applied as necessary to pick up analogue to the drug “Leflox”. Price counterparts below, the effect of their use is similar.

“Leflox” refers to serious medicines and can cause a lot of side effects. Before applying it is important to carefully study the manual. Its use for the treatment should be carried out only after a doctor's prescription, which will track the changes occurring in the body.