Renal failure is called the progressive deterioration of renal function due to the loss of nephrons, chronic illnesses provoked by. Gradual loss of functions can lead, as a rule, to malfunction of the whole organism, as well as to the emergence of various complications of certain systems and organs.
There are several forms of this disease: latent, intermittent, and offset of the terminal. Diagnostic steps to determine the disease involve the holding of a special clinical and biochemical analyses of samples Rehberg and the General, ultrasound, Doppler ultrasound of renal vessels, etc. the Treatment of this disease based on the suppression of the primary disease and symptomatic treatment and extracorporeal hemocorrection.
Chronic renal failure considered to be an irreversible violation of the excretory and filtration of their functions, until the complete destruction of renal tissue. The pathological process is progressive course. With the development of the disease there is a buildup of symptoms, which include weakness, loss of appetite, vomiting, swelling, nausea, dry skin, etc. Sharply decreased urine output, in some cases – to complete its termination. In the later stages may develop heart failure, pulmonary edema, tendency to bleeding, encephalopathy, uremic coma. In this case, the patient is shown to hemodialysis and kidney removal.
What are the causes? Depending on them are divided into acute renal failure:
The Chronic form occurs because:
Kidney failure can result from glomerulonephritis, hereditary nephritis, inflammation of the kidneys in systemic diseases chronic pyelonephritis, amyloidosis, or polycystic disease, and glomerulosclerosis in diabetes mellitus, nephroangiosclerosis and other diseases that affect both or one kidney.
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The Main feature of this pathological process is the progression of the loss of nephrons. In the early stages of the disease kidney function becomes more relaxed, then there is a significant reduction of their functions. Histological studies confirm the loss of renal parenchyma, which is gradually replaced by connective tissue cells.
The Development of the patient's kidney failure usually precedes the emergence of chronic diseases in the period from 3 to 10 years and sometimes more. The development of renal disease before the occurrence of chronic insufficiency can be divided into certain stages, and is directly dependent on the choice of tactics of treatment of this disease.
There are the following stages of this pathological process:
Changes in the patient's blood: anemia, which is due to inhibition of hematopoiesis and reduction of the life period of erythrocytes. There are also clotting: thrombocytopenia, prolongation of the period of bleeding, decrease the amount of prothrombin.
Complications developing in the lungs and the heart: arterial hypertension (almost half of the patients), heart failure, myocarditis, pericarditis, uremic pneumonitis (in later stages).
Changes in the nervous system: in the early stages – sleep disturbance and distraction, at a later – slow reactions, confusion, delirium, hallucinations, peripheral neuropathy.
Disorders in the digestive organs: in early stages-loss of appetite, dry mucous membranes of the mouth, belching, nausea, stomatitis. Due irritation can develop enterocolitis, and gastritis atrophic form. Formed ulcerative lesions of the stomach and intestines, which are often the source of bleeding.
The pathology of the musculoskeletal system: renal disease in men and women have different forms of osteodystrophy – osteosclerosis, osteoporosis, osteitis fibrous nature, etc. Clinical symptoms of osteodystrophy are spontaneous fractures, compression of the vertebrae, deformation of the skeleton, arthritis, pain in muscles and bones.
The part of the immune system is often observed the development of lymphocytopenia. A decrease in immune defenses causes an increase in the incidence of septic formations.
Consider the impact of renal insufficiency in women and men.
In the period that precedes the development of this pathological process, renal function is preserved in full volume. The levels of glomerular filtration are not violated. At subsequent stages of the glomerular filtration rate begins to decline, and the kidneys lose the ability to concentrating urine, which suffer from renal processes. Homeostasis at these stages is not impaired. However, as the number of functioning nephrons is reduced and the patient begin to appear the first signs of kidney failure.
Patients with latent stage of the disease complaints are usually not present. In some cases, they can note slight weakness and fatigue. Patients with renal insufficiency compensated stage may be concerned about increased in fatigue. With the development of intermittent stage, there are already more pronounced symptoms. The weakness increases, the patient may complain of constant thirst and loss of appetite. Their skin is pale, dry. At the terminal stage, patients usually lose weight, their skin acquires a grayish-yellow color, becomes flabby. Also for this stage the pathology is characterized by: itching, loss of muscle tone, hand tremor, muscle twitching, increased thirst and dry mouth. Also may be the appearance of apathy, drowsiness, lack of focus.
When you enhance the process of intoxication begins to appear typical of breath, nausea. Periods of apathy, as a rule, replaced by anxiety, inadequacy. Also in this case, the characteristic manifestations of degeneration, hoarseness, hypothermia, aphthous stomatitis. The stomach of the patient is distended, there is often vomiting and diarrhea of dark color. Patients also may complain of painful itchy skin and muscle twitching. Increasing the degree of anemia develop hemorrhagic syndrome, and renal osteodystrophy. Typical manifestations of kidney failure in women this phase are: ascites, myocarditis, encephalopathy, pericarditis, uremic coma, pulmonary edema.
If you suspect the development of this pathology it is necessary to conduct certain laboratory studies:
Tests for renal failure prescribed by the doctor.
In addition, it is necessary to conduct an ultrasound to determine the size of the parenchymal thickness and the overall size of the kidneys. Doppler ultrasound of the blood vessels will reveal the blood and main blood vessels. In addition to this there is also such a study as x-ray contrast urography, however, it should be used with caution, because many contrast agents have a high toxicity in relation to renal cells.
What constitutes timely therapy aimed at slowing the development of renal failure and reduced clinical symptoms of the disease?
The Main aspect here is the treatment of the underlying disease that caused the development of this pathology. The patient will need special diet. If necessary, he can be assignedantibacterial drugs and anti-hypertensive medications. It is also shown sanatorium and resort treatment. In addition, it requires careful control over the level of glomerular filtration, renal blood flow, the concentration of kidney function, level of urea and creatinine.
With changes of homeostasis it is possible to conduct correction of the acid-alkaline composition, water and salt balance of the blood. It should be noted that symptomatic therapy is usually the treatment of anemia, hemorrhagic and hypertensive syndromes, and also in maintenance of cardiac function.
Patients who suffer from this pathology, are assigned a low-protein diet with a large amount of calories, which includes a large number of essential amino acids. It is necessary to reduce the amount of salts, and the development of hypertension – eliminate the consumption of salt.
The Content of protein in the diet of a patient should depend on the degree of renal function: when glomerular filtration rate below 60 ml/min amount of protein should be reduced to 40 grams a day, but if the rate is below 30 ml/min - up to 25 grams per day.
The emergence of the renal osteodystrophy of patients prescribed vitamin D preparations with high content of calcium, however you need to remember about the calcification of organs – very dangerous morphological process caused by high doses of vitamin D. To reduce hyperphosphatemia appointed sorbitol and aluminum hydroxide. Condition is during treatment the level of calcium in the blood and phosphorus.
Anemia is assigned, as a rule, preparations with a high iron content, folic acid, androgens. At lower hematocrit transfusion are erythrocyte mass. The use of chemotherapeutic drugs and antibacterial drugs determined depending on the manner in which they will appear. The dose of sulfonamide, ampicillin, cephaloridine, penicillin and methicillin is reduced in this case several times, and when you receive polimiksina, monomitsin, neomycin and streptomycin may be the development of certain complications, such as neuritis of the auditory nerve, etc. to Patients suffering from renal insufficiency, contraindicated nitrofurans.
The use of the glycosides in the treatment of such consequences of this disease like heart failure should be strictly under the control of the specialist and laboratory parameters. The dosage of such medication is reduced with the development of hypokalemia. Patients with intermittent stage renal disease, especially during exacerbations, is assigned to hemodialysis.
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Alin Trodden - author of the article, editor
"Hi, I'm Alin Trodden. I write texts, read books, and look for impressions. And I'm not bad at telling you about it. I am always happy to participate in interesting projects."
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