Proton pump inhibitor list of drugs, mechanism of action, reviews


2019-03-09 15:00:43




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From problems with digestion, heartburn and gastritis suffer more than 90 % of the population, but few know that drugs designed to alleviate the condition, have long existed and are widely used in medical practice in cases where antacids do not help. We will understand what a proton pump inhibitor list of drugs also consider.

Where in the human body come from the pump?

proton pump inhibitor list of medicationsProton pump, aka proton pump-enzyme is a protein that promotes the development of hydrochloric acid in the stomach. It is a necessary and important action for the process of digestion. However, it often happens that the acid begins to produce in large quantities, which leads to unpleasant and painful sensations in the stomach.


Proton pump Inhibitor (drug list is shown below) is used quite often.

Inhibitors, or proton pump inhibitors-drugs which is treatment of diseases of the gastrointestinal tract associated with acidity:

- gastritis, including erosive;

- stomach ulcer and duodenum;

- duodenitis-inflammation of the mucous membrane of the duodenum;

- GERD-reflux disease, in which the contents of the stomach regularly thrown into the esophagus, which over time is being eroded mucous of esophagus, trachea and pharynx;

- dyspepsia-disorders of digestion, where there is a feeling a stabbing/cutting pain in the epigastric region (the area of the solar plexus) after a meal;

- effects of nonsteroidal anti-inflammatory drugs (such as "Diclofenac"), irritating the mucous membranes of the gastrointestinal tract;

- zollingerellison syndrome-gastrinoma-a malignant tumor that causes increased secretion of hydrochloric acid.

In all these cases is shown taking a proton pump inhibitors.

Mechanism of action

Tablets or capsules PPIS are taken inside orally, dissolve in the small intestine and are transported with the blood through the liver into the secretory canaliculi, where and begin to accumulate. By acting directly on the tubules, which produce hydrochloric acid, inhibitors decrease its secretion, respectively, reduces the aggressiveness of gastric juice.


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Proton pump Inhibitor (the list of drugs available in any pharmacy) is prescribed by a doctor.

The Mechanism of all drugs of this type are the same, but different concentration of the active substance, which keeps the level of pH, and speed of impact. Pick them up can only be a doctor after measurements of acidity, it is performed during the day. Then assigned an appropriate remedy, and monitored its effectiveness. If does not come easy, and this is possible in the case of resistance to drugs of this kind, it is necessary to find a replacement.

In terms of pH focused on the condition of acidity of the gastrointestinal tract. Total units 14, water neutral, is in the middle of acid-base balance and has a pH of 7. At the bottom from the water side is acid environment, at the top – alkali.

proton pump inhibitors are the drugs of the new generationFor different types of diseases associated with increased production of hydrochloric acid, characterized by different value of pH standards. For example, duodenal ulcer is able to heal at a pH of greater than 3 during the day, and to kill the bacterium Helicobacter pylori, the necessary acidic environment where pH is greater than 5.

According to the normal pH and to diagnosis, the doctor prescribes a particular drug from the group of proton pump inhibitors in a certain dosage for a certain period.


The treatment may take several months or even years. For example, the drug "Rabeprazole" manual and describes the length of treatment. Proton pump Inhibitors safe for the body, because they act locally and do not cause habituation, that is, after completion of the course can not be afraid of the so-called “withdrawal”. This type of medicines do not choke the disease, and it completely heals.

Now I understand what is a proton pump inhibitor. The list of drugs is very extensive.

Group of blockers of the proton pump

pantoprazole usage instructions price“R” is a well-known drug. Available:

- “Omeprazole-akri”.

- “Omeprazole-Richter” – the most potent option.

- “Omeprazole Sandoz”. The combined tool is used rather to adjust the production of hydrochloric acid and the gastrointestinal tract.

Long been known that “R” - a proton pump inhibitor, but today it is preferred to appoint less often, because new generation drugs are the best how effectiveness and side effects.

Introduction not only orally, but also intravenously, which contributes to obtaining a quick result. The disease recurrence was not observed during 10 years of observation for patients.


In eachthe package includes to the drug "Pantoprazole" instructions for use. The price of the drug is an average of 130 rubles.

"Pantoprazole" with great care, but is prescribed during 2 and 3 trimesters of pregnancy if the potential benefit expected is much higher than the risk to the child. Tests on pregnant women have not been conducted, but the animals have negative effects on the fetus were noted.

lansoprazole manualBefore using "Omeprazole" and "Pantoprazole" you must read an extensive list of drug interactions and consult a doctor if the admission of any drug from this list is planned simultaneously with other medicines. Analogue – “Nolpaza”.

nolpaza why prescribeWhy prescribe this drug? It is also a proton pump inhibitor. Available in two forms-in tablets and ampoules for injection. But in fact, ampoules – it is a lyophilisate, from which a solution for injection. Most often prescribed for peptic ulcer disease, but successfully applied in other diseases of the gastrointestinal tract.

Thanks to the drug, gastric juice is produced to a lesser extent, the mucosa is irritated not so much. If there are ulcers and erosion, they gradually calm down. Copes with it “Nolpaza”. Why prescribe a drug, became clearer. Counterparts – “Lanza”, “LanSafe”, “Loanser-sanovel”, “Epicurus”, “Acrilan” etc. is Limited is used in the treatment of pregnant women and children, the application is not desirable, if you can pick up another drug.

“Rabeprazol” – another drug from the group of blockers of the proton pump.

The drug “Rabeprazol” the statement specifies that it is incompatible with liquid antacids. Enhanced action when administered simultaneously with ‘Warfarin", "Diazepam" "Theophylline” and “Phenytoin”. Counterparts – “Beret”, “Salesman”, “Noflux”, “Pariet”, “Rabelo”, “Harbeson” etc.

rabeprazol instruction"Lansoprazole” – effective drug for diseases of the gastrointestinal tract. Produces blocking the gastric juice secretion. This confirms to the drug "Lansoprazole" manual. In addition, the drug fights the bacteria Helicobacter pylori. Specific antibodies to it are produced heavily due to the action of the drug. Maximum this drug works the first few days of starting it. Counterparts – “Manera”, “Nexium”, “Losec”, “Sampras” etc. Certain medications taken concurrently with ‘Lansoprazole" is able to increase its concentration in blood plasma and enhance the effect. This "Imipramine”, “Clomipramine”, “Citalopram”. "Diazepam” and “Phenytoin” increase the content slightly, and “Ketoconazole”, “Itraconazole” and “Clarithromycin” reduce effectiveness of the drug. Describes "Lansoprazole" instructions for use.

“Esomeprazole” – a good drug when ulcers stomach and duodenal ulcers. Can be used along with antibiotics. Treats in the acute phase of disease and is used to prevent. Inhibits the proliferation of Helicobacter pylori. The drug ‘Esomeprazole" (capsules and solution for injection) is used during the month at a dosage of 40 mg per day. For prevention, the dosage may be halved.


On the background of treatment with blockers of the proton pump symptoms of cancer can become low, therefore before starting therapy needs to be examined to exclude the occurrence of tumors. Moreover, urgent research is required with frequent vomiting, especially of blood disorders of the chair and change its color and smell, as well as severe weight loss. So, with caution should take ‘Rabeprazole sodium”.

This group of drugs, according to recent studies, increases bone fragility, respectively, and the risk of fractures, but it also encourages associated diarrhea (that is caused by taking certain medications), hypomagnesemia and manifestation of dementia in the elderly.

For this reason, a doctor must first prescribe the lowest possible dosage or possibly a short course of treatment and observe the effect.

Use of antibiotics

Proton pump Inhibitors (new generation drugs) are used in the treatment of diseases caused by the bacterium Helicobacter pylori, which may contribute to problems of the gastrointestinal tract and provoke relapses have seemingly cured of the disease. In this case, the treatment added antibiotics, mainly tetracycline.

This is a group of strong antibiotics, so in any case you cannot assign them yourself.

Side effects

As with any medication, proton pump inhibitors there are a number of possible side effects:

  • Increasing drowsiness – therefore this type of drugs prohibited for use by persons whose activities require attention and quickness of reactions, for example for drivers.
  • Headaches, verging on migraines – protivomigrenoznae funds is not prohibited to receiveconcurrently with IPP, but consultation of the doctor is desirable;
  • Dizziness, and weakness;
  • Pain in the legs, spine, joints;
  • Digestive problems-diarrhea or constipation, nausea;
  • Changing the taste;
  • Dry mouth;
  • Allergic reactions-hives, itching;
  • Slowing the formation of blood cells-leukocytes, and platelets;
  • Increased sweating, chills.

In these cases necessarily is informed by the attending physician, who, as a rule, appoint another suitable drug PPIS.

We must note that side effects occur quite rarely and often poorly developed, therefore, under the supervision of a physician a further application is possible.

If you use proton pump inhibitors (new generation drugs), side effects practically do not exist.


omeprazole proton pump inhibitorGeneral contraindications for all proton pump inhibitors are:

- Period of lactation and pregnancy, especially 1st trimester, use of certain drugs in this group in the 2nd and 3rd trimesters may with the consent of the doctor. These drugs are highly bioavailable, i.e., able to penetrate tissues, including the placental barrier and can accumulate in breast milk. Although there are no confirmed data about the dangers of these funds to the fetus, there is no feedback, except for experiments with animals.

- Children up to age 12 years because their work is of the endocrine glands is under development, so any interference may cause a crash.

- Allergy or hypersensitivity to the drug.

For Example, all this describes to the drug "Pantoprazole" instructions for use.


Prices of drugs-blockers of the proton pump range widely, but they are quite affordable. On average the cost is from 90 RUB. per pack "Omeprazole" to 500 roubles for packing other new generation drugs.

The Price also depends on the number of capsules/tablets in the package and country of origin. For example, the Russian generics can be bought for 20-100 RUB, but you have to understand that generics – this is not the original means. They often lower efficiency and worse portability, higher risk of side effects.


Drugs in this group mostly cause positive feedback. They are really effective in diseases of the gastrointestinal tract. The cost is very acceptable.

There are of course some side effects, such as diarrhea. But they manifest in rare cases, and if we find the right dosage, they will not be at all.


Proton pump Inhibitors are constantly being improved. This involved scientists from different countries of the world. About 6 years ago was released the drug “Dexlansoprazole”. It is not yet approved for use without restrictions, but gastroesophageal reflux disease use it to treat quite successfully.

At present, Japan is being developed ‘Tenatoprazole”, which is positioned as the most effective blocker of the proton pump.

Korean ‘Reprisal” works much smoother and faster "Omeprazole" however, in Russia, the US and the EU it is banned for use for unknown reasons.

Drugs in this group are often 1-2 times a day, which makes their use convenient. But, they should appoint only the doctor after taking a history and examination, because each of the drug its properties, and each person has their own characteristics of the disease. We examined the proton pump inhibitors. The mechanism of action are also described.

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