If to relieve the pain with oral medication is not possible, then use the solution for injection “Caver”. Instructions for use injections advises to do in case of pain syndrome of moderate and high severity. This may be the postoperative condition of the patient, renal colic or lumbar pain.
1 ml of solution for injection is 25 mg of active substance - dexketoprofen. To support ingredients substances include ethanol in an amount of 96%, sodium chloride, sodium hydroxide and water for injection.
The product is a clear colorless liquid. Packaged in glass ampoules which are enclosed in a carton of 5-10 pieces. Each ampoule contains 2 ml of the drug “Caver”.
Instructions for use injections relates to non-steroidal anti-inflammatory and Antirheumatic drugs are derivatives of propionic acid.
Dexketoprofen trometamol (the active substance of this drug) is a salt of propionic acid. Characterized analgesic, antipyretic and anti-inflammatory properties. Belongs to the class of nonsteroidal anti-inflammatory drugs, or NSAIDs.
The Mechanism of aims to reduce the synthesis of prostaglandins in the result of inhibition of cyclooxygenase. That is, slows down the conversion of arachidonic acid to PGG2 and PGH2 endoperoxide cyclical nature. Of them, in turn, formed prostaglandins PGEi, PGE2, PGF2a, PGD2, including such substances as prostacyclin PGI2, and thromboxane Thug and Thug. Suppression of prostaglandin synthesis affects the pulses of the inflammatory process, for example, kinins, affecting the basic function of medicine. Revealed the overwhelming influence of dexketoprofen on the activity of cyclooxygenase-1, cyclooxygenase-2.
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Clinical trials have established the analgesic action of the drug at different degrees of pain. Discovered its analgesic properties by the injection of a solution inside. The analysis was carried out intensive effect on pain in the postoperative intervention. This orthopedic and gynecological surgical procedures, as well as operations on the abdominal cavity. Used in different degrees of pain medication “Caver”. Instructions for use injections recommends to do and in renal colic.
Studies have shown that medical treatment acts instantly and its maximum efficiency is manifested for forty five minutes. Analgesic effect on the body lasts about eight hours, but only on condition that there was at least 50 mg means “Caver" (injections). Description, indications to the drug is very important to learn before using it.
Intramuscular administration of trometamol dexketoprofen the highest concentration is observed in about twenty minutes. Has a high degree of connections of blood plasma proteins-99%. Distribution of dexketoprofen is around 0.25 l/kg. Period of poluraspredelenia is 0.35 hours. Appears after 1-2,7 hours.
It Should be injected intramuscularly or intravenously in acute pain syndrome of moderate and high intensity drug “Caver”. Instructions for use injections advises to do only in the case when not helping oral therapy. They should be used after surgery, if you experience renal colic and severe pain in the lumbar region.
It Has a drug “Caver" (injections) indications and contraindications. The second include:
Do Not disregard any of these factors when prescribing the drug “Caver" (injections). Instruction manual describes all the features of the proper use of this drug.
The Drug is not prescribed small patients due to insufficient knowledge of its effects on the child's body. With caution should take it and the elderly.
For adults, the recommended dose of injection is 50 mg. the Interval between injections should be at least 8-12 hours. If necessary, the second injectioncarry out six hours later. Daily dose is 150 mg. the Drug is used for occasional relief of acute pain. It is not used more than two days in a row. After the initial pain, if the situation allows, the patient transferred to oral painkillers.
Side effects on the body cut by the introduction of the minimum dose. After surgery, if pain is strong and moderate degree of severity, the drug is used strictly according to indications. Possible compatibility of the medication with opioid analgesics.
The elderly the dose is not correct. But since the exchange processes in the kidneys in older age slow down, it is still recommended to reduce the dosage. Maximum permissible dose for a minor breach of the kidneys is 50 mg.
Patients with diseases of the liver (5-9 points on a scale child-Pugh) reduce the daily dose to 50 mg. After administration of the drug in the body carefully monitor the work of this body. The more severe stage of liver disease medicine not prescribed (10-15 points on a scale child-Pugh).
In mild renal disease (creatinine clearance is 50-80 ml/min) daily dose should not exceed 50 mg. With an average or severe violations of the kidneys, which creatinine clearance is < 50 ml/min, the drug is strictly prohibited.
The Solution for injection is administered as intramuscularly and intravenously. Intramuscular manipulation is administered slowly and deep enough “Caver" (shots).
The liquid in the 2 ml vials for injection into a vein should be diluted. The contents of the vial need to add 30-100 ml of 0.9% sodium chloride, glucose or lactic ringer solution. Liquid for intravenous injection is prepared in sterile conditions. Cooked substance must be absolutely clear and have no impurities. The infusion is carried out for ten to thirty minutes. Do not allow the penetration of daytime sunlight for a solution during its preparation and during drug administration.
“Caver” (injections in ampoules) manual recommends to combine with the drug to dissolve. To do this, in 2 ml vials need to add 100 ml of 0.9% sodium chloride. If necessary, the drug can be diluted with glucose in the same ratio.
It is Forbidden to combine in a solution for injection "Promethazine” and “Pentazocine" medication “Caver" (shots).
How to apply the medicine bolus if the introduction? To this end, the infusion solution with a volume of 2 ml must not be diluted. Pour quickly, for fifteen seconds. This time, the introduction should not be reduced. In small doses it is permissible to combine ‘Camera” such injection fluids, such as “Heparin", "Lidocaine", "Morphine" and "Theophylline".
Do Not mix the injection liquid with low-dose "Dopamine”, “Promethazine”, “Pentazocine”, “Pethidine” and “Hydrocortisone". This is recommended because of the risk of the appearance of a white precipitate, which is highly undesirable during the procedure.
The Drug is not subject to even momentary storage and should be administered immediately after collection of glass vials. The solution should also be applied immediately after mixing all the necessary medicines. Responsibility for the correctness of the procedure falls entirely on the provider.
The Injection solution after cooking retains all the properties unchanged for the day. This condition is satisfied if the prepared product is fully protected from daylight and temperature conditions not exceeding 25°C.
Ampoule “Camera” intended for one-time injection. The remaining solution was immediately utilized. Just before infusion, ensure that the solution is transparent and has no color coating. If there are any solid particles of the drug cannot be used.
You May experience a number of side effects after drug administration “Caver" (injections). Include information that quite often there are phenomena such as nausea and vomiting. There is pain in the injection site, bleeding, inflammation and hematoma. Sometimes there is anemia and insomnia, dizziness, drowsiness and headache. Rarely recorded fever and fatigue, blurred vision, chills. It was noted pain in the abdomen, indigestion. After the injection sometimes there is diarrhoea or constipation, vomiting with admixture of blood. Was noticed excessive dryness of the mouth. Some patients were concerned about dermatitis, itching, rashes and excessive sweating.
In rare instances, marked hyperglycemia, hypertriglyceridemia and anorexia. There was paresthesia and unconsciousness. Worried sick ringing in the ears, premature beats and tachycardia. In rare cases, was fixed symptoms of hypertension, thrombophlebitis, bradypnea. Had ulcer, jaundice, hives, troubled acne, muscle rigidity, stiffness of the joints. Observed convulsions in the muscles and pain in the back. Partially observed increased urine formation, renal colic, acetonuria. Happened disruptions of the menstrual cycle and functioning of the prostate gland. It was observed tremor of the muscles, peripheralswelling.
In exceptional cases were noted in patients neutropenia and thrombocytopenia. A few examples indicate anaphylactic reactions for example, anaphylactic shock. Very rarely bronchospasm, shortness of breath. Bother sometimes, pancreatitis and Stevens-Johnson syndrome, epidermal necrolysis. Patients suffer after the introduction of injection from angioneurotic edema, swelling of the face, photosensitivity. Fixed that one in ten thousand cases of nephritis and nephrotic syndrome.
Officially established facts of the overdose was not identified. If you exceed the recommended doses of the drug negatively affects the digestive tract, causing vomiting, pain in the abdomen and anorexia. There may be drowsiness and disorientation in space, dizziness, headaches. In case of overdose should immediately take certain measures and to withdraw the drug from the body using dialysis.
The High price of the drug is different “Caver" (injections). Analogs of this drug can be found in any pharmacy. The same ATC code active ingredient from the following drugs:
These medicines may, if necessary, completely replace the “Caver" (injections). Analogs and substitutes of this drug act in a similar way and have exactly the same active ingredient, but they should not be pick your own. Before replacement of one drug to others should be consult a doctor who will help you to choose the most suitable option.
Made in Ukraine, the drug “Caver" (injections). The instructions recommend to use it not regularly but only from time to time and no more than two days. In Russia, this drug is not widespread and is not sold in pharmacies so it is possible to identify only an approximate price. It was formed in translated from hryvnia to the Russian ruble in accordance with the official rate which is currently 1 UAH. equal to 3.21 RUB In Ukraine this drug can be bought for 200 hryvnia. The conversion price will be equal to 640 Russian rubles.
No need to store more than two years from the time of manufacture specified on the packaging, medication “Caver" (injections). Description to medicine notes that at the expiry date the drug is unfit for use. To keep a product must in the original box at temperatures not exceeding 25°C. the Medication must be in a cool, inaccessible to children place and be protected from direct sunlight.
Available from pharmacies strictly by the recipe. Manufacturer is Ukrainian company PJSC “products”.
“Caver” is a reliable and highly efficient preparation of superovaya acute pain. Designed for a short use. Appeared on the market relatively recently and have not had time to Woo consumers. It can be purchased through Internet pharmacies and major drugstores in big cities of Ukraine.
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