Among the ACE inhibitors used in the treatment of hypertension and heart failure, the most famous is the French drug “Prestarium”. Medicine it has a vasodilator effect. His second name – “Perindopril". At the pharmacy you can buy analog «Prestarium" medication “Coversyl”. There are other, similar drugs ‒ the ‘Aceon”, “AZERTY”, “Coversum”, “Precum”.
By taking any of these medications in patients recovering elasticity of the large arteries, reduced excess subendothelial collagen, pre - and afterload on the heart, decreases myocardial hypertrophy.
Active substance which contains analogue and ‘Prestarium”, and the drug ‒ perindopril – has a positive effect on the heart, facilitating its work, reducing the filling pressure of the ventricles, making less the frequency of its contractions.
The Drug “Prestarium" (tablet) is rapidly absorbed and its maximum effect is already visible after four to six hours, the very same pharmacological effect persisted throughout the day. Perindopril is excreted through the kidneys.
Pressure with regular intake of drug stabiliziruemost during the month. Ceasing to take the drug “Prestarium”, the patient does not feel withdrawal, the effect of the ACE inhibitor does not stop abruptly. The more vulnerable patients, stabilization of blood pressure occurs faster.
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If this medication or equivalent “Prestarium" (drugs ‘Aceon”, “AZERTY”, “Coversum”, “Precum” or “Coversyl”) is used in the treatment of heart failure, it is important that blood pressure when taking (doctor prescribed dose) does not change sharply or after the first pill, or after more long-term use of drugs.
Contraindications for use as pharmaceuticals ‘Prestarium" and its analogues are:
If this inhibitor of angiotensin converting factor assigned to the patient with renal failure, the doctor he will prescribe a reduced dose and will periodically monitor the levels of potassium.
Any equivalent “Prestarium”, as the drug has side effects. This:
Hypotension – these are the symptoms of overdose "Perindopril". When this is washed stomach, is administered intravenously saline, and, in severe cases, hemodialysis is done as an active ingredient of the drug is amenable to dialysis.
Usual dosage of the medicine – 1 tablet per day, taken inside the morning before a meal. Note that taking the medication with food slows down the action of perindopril.
The Starting dose for heart failure is 2 mg, and support – 4 mg hypertension dosage a little higher – 4 mg if the treatment is slow and can not see the effect, then after a month of therapy it was increased to 8 mg.
If the patient has stage 4 heart failure, low blood pressure, kidney failure, or if it's an elderly person, it is recommended to start therapy with 2 mg.
Produced the drug in tablet form for 4, 5, 8 and 10 mg. Tablets covered with film and Packed in blisters of 14 or 30 pieces each.
The Cure «Prestarium” belongs to the list B. Holiday from drugstores according to the recipe.
It should be Stored not more than two years and when the air temperature is not above 30°C.
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