The Drug is manufactured in 3 dosage forms-suspensions, dispersible and conventional tablets. The suspension is a pleasant smell, with a hint of yellow and is quite characteristic of this drug taste. The suspension can registerroutes when shaking the bottle.
Tablets are available nearly white with a slight yellowish tinge. The pills are round shaped, biconvex, both its surface smooth.
Pharmacological action of the drug
Pharmacological action belongs primarily to the Nise tablets, the instruction contains the data for all dosage forms. The drug is a NSAID containing in its structure sulphonamido group. Nimesulide may apply to COX-2 inhibitors, so that it has anti-inflammatory and analgesic effects, in addition, drug having and analgesic effects, but to a lesser extent.
The Mechanism of action of the drug is associated with suppression of the synthesis of prostaglandins in inflammation and suppress the formation of oxygen radicals and inhibition of release of myeloperoxidase.
Nise readily absorbed from the gastrointestinal tract, reaching its maximum in the blood in 2 hours. The drug is 99 % bound to proteins.
Nise – pills, instructions for which are taken from official sources, metaboliziruetsa in the liver, and excreted in the urine, and 98 % of the dose is excreted during the day.
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Side effects of Nise
Pill guide to which now is, can give side effects to various systems and organs:
Side effects of the drug, which belong to the digestive tract
Side effects of the drug, which belong to the CNS:
Side effects of the drug that are related to allergic reactions.
Other side effects:
The following list of contraindications in which it is recommended to avoid taking the drug, and when absolutely necessary, only after consulting a doctor.
Drug interactions Nise
Tablets, the instruction on the application of which does not complete and comprehensive data about all drug drug interactions is as follows: it is not recommended to apply together with the following medicines-phenytoin, digoxin, any diuretic, drugs lithium, anticoagulants, antihypertensives, other NSAIDs, methotrexate, cyclosporine.
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