Nise (tablets) instructions for use.

Pharmaceutical form

The Drug is manufactured in 3 dosage forms-suspensions, dispersible and conventional tablets. The suspension is a pleasant smell, with a hint of yellow and is quite characteristic of this drug taste. The suspension can registerroutes when shaking the bottle.

Tablets are available nearly white with a slight yellowish tinge. The pills are round shaped, biconvex, both its surface smooth.

Nise composition:

Suspension

Active substance

• Nimesulide-50 mg (5 ml suspension)

Excipients:

• Sorbitol
• Glucose
• Xanthan gum
• Propylparaben
• Methylparaben
• Citric acid
• Pineapple flavor
• Yellow WS dye
• Glycerol
• Polysorbate
• Water purification

Dispersible Tablets

Active substance

• Nimesulide-50 mg (1 table.)

Excipients

• Aspartame
• Calcium phosphate
• Microcrystalline Cellulose
• Carboxymethyl starch
• Corn Starch
• Talc
• Magnesium stearate
• Colloidal silicon dioxide
• Pineapple flavor

Tablet

Active substance

• Nimesulide-100 mg (1 table.)

Excipients:

• Magnesium stearate
• Calcium hydrogen phosphate
• Microcrystalline Cellulose
• Colloidal anhydrous Silica
• Corn Starch
• Glycolate starch sodium
• Purified Talc

Pharmacological action of the drug

Pharmacological action belongs primarily to the Nise tablets, the instruction contains the data for all dosage forms. The drug is a NSAID containing in its structure sulphonamido group. Nimesulide may apply to COX-2 inhibitors, so that it has anti-inflammatory and analgesic effects, in addition, drug having and analgesic effects, but to a lesser extent.

The Mechanism of action of the drug is associated with suppression of the synthesis of prostaglandins in inflammation and suppress the formation of oxygen radicals and inhibition of release of myeloperoxidase.

Pharmacokinetics

Nise readily absorbed from the gastrointestinal tract, reaching its maximum in the blood in 2 hours. The drug is 99 % bound to proteins.

Nise – pills, instructions for which are taken from official sources, metaboliziruetsa in the liver, and excreted in the urine, and 98 % of the dose is excreted during the day.

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Indications

• Rheumatic diseases which develop outside of the joint capsule
• Osteoarthritis
• Inflammation and pain after surgery
• The Pain caused by dysmenorrhea
• Fever and pain during acute inflammation in the upper Airways

Side effects of Nise

Pill guide to which now is, can give side effects to various systems and organs:

Side effects of the drug, which belong to the digestive tract

• Nausea
• Heartburn
• Stomach Pain
• Tarry stools

Side effects of the drug, which belong to the CNS:

• Headaches
• Drowsiness
• Dizziness

Side effects of the drug that are related to allergic reactions.

• Erythema
• Skin rash
• Hives

Other side effects:

• Delay in the body fluid
• Oliguria
• Swelling

Nise contraindications

The following list of contraindications in which it is recommended to avoid taking the drug, and when absolutely necessary, only after consulting a doctor.

• Bleeding from the digestive tract
• Kidney failure
• Liver failure
• Pregnancy and lactation
• Peptic Ulcer disease of the gastrointestinal tract

Drug interactions Nise

Tablets, the instruction on the application of which does not complete and comprehensive data about all drug drug interactions is as follows: it is not recommended to apply together with the following medicines-phenytoin, digoxin, any diuretic, drugs lithium, anticoagulants, antihypertensives, other NSAIDs, methotrexate, cyclosporine.